ETS转录因子：从癌症进展到肿瘤免疫的多面手。
ETS transcription factors: Multifaceted players from cancer progression to tumor immunity.
发表日期：2023 Feb 23
作者：
Yufei Wang, Zhao Huang, Mengyu Sun, Wenjie Huang, Limin Xia
来源：
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
摘要：
E26转录因子（ETS）家族包括28种转录因子，其中大多数参与肿瘤的发生和发展。作为一群功能异质性的基因调控因子，ETS因子具有结构上一致的DNA结合结构域。作为控制不同细胞功能的最重要的转录因子家族之一，ETS激活受多个细胞内信号通路和翻译后修饰的调节。ETS活性的异常变化通常导致癌基因性异常，包括癌细胞的存活、生长、增殖、转移、基因不稳定性、细胞代谢和肿瘤免疫等。本文系统地阐述了ETS因子的基础和研究进展，从它们在肿瘤方面的相关性到临床性应用，特别关注ETS家族在肿瘤免疫中的作用，旨在阐明ETS因子的重要作用和临床调控潜力。版权所有©2023 Elsevier B.V. 发表。
The E26 transformation specific (ETS) family comprises 28 transcription factors, the majority of which are involved in tumor initiation and development. Serving as a group of functionally heterogeneous gene regulators, ETS factors possess a structurally conserved DNA-binding domain. As one of the most prominent families of transcription factors that control diverse cellular functions, ETS activation is modulated by multiple intracellular signaling pathways and post-translational modifications. Disturbances in ETS activity often lead to abnormal changes in oncogenicity, including cancer cell survival, growth, proliferation, metastasis, genetic instability, cell metabolism, and tumor immunity. This review systematically addresses the basics and advances in studying ETS factors, from their tumor relevance to clinical translational utility, with a particular focus on elucidating the role of ETS family in tumor immunity, aiming to decipher the vital role and clinical potential of regulation of ETS factors in the cancer field.Copyright © 2023. Published by Elsevier B.V.