年轻成人（<50岁）患有结直肠癌，可能会出现延误诊断和治疗的情况，这与不良结果有关。我们旨在比较大量人群中CRC患者的年龄延误间隔。这是一项基于人口的研究，研究对象是在2003年至2018年期间在加拿大安大略省被诊断出患有CRC的成人。我们测量呈报到就诊和确诊之间的时间（诊断间隔）、确诊和开始治疗之间的时间（治疗间隔）以及呈报到就诊到治疗之间的时间（总间隔）。我们使用多元量位回归比较了<50岁、50-74岁和75-89岁的成年人之间的间隔长度。共有90,225名CRC患者列入该研究。其中，6,853名患者（7.6％）年龄在50岁以下。相比中年患者，年轻患者更有可能是女性、紧急就诊、患有IV期疾病以及患有直肠癌。与近端结肠癌相比，女性性别（8.7天，95％CI为6.6至10.9）和直肠癌（9.8天，95％CI为7.4至12.2）都与较长的总间隔有关。调整后，与中年患者相比，<50岁患者的诊断间隔显著延长（4.3天，95％CI为1.3至7.3），而治疗间隔显著缩短（-4.5天，95％CI为-5.3至-3.7）。但是，总间隔差异并不显著（-0.6天，95％CI为-4.3至3.2）。在分层模型中，紧急就诊的年轻成人患有第IV期疾病，以及年龄大于75岁的患者总间隔更长。年轻成人更容易患有第IV期结直肠癌，但就诊到治疗的时间与有筛查资格的老年成人相似。版权所有©2023 AGA协会。由Elsevier出版公司发表。保留所有权利。

Younger adults (<50 years) with colorectal cancer may have prolonged delays to diagnosis and treatment that are associated with adverse outcomes. We aimed to compare delay intervals by age for CRC patients in a large population.This was a population-based study of adults diagnosed with CRC in Ontario, Canada from 2003 to 2018. We measured time between presentation and diagnosis (diagnostic interval), diagnosis and treatment start (treatment interval), and the time from presentation to treatment (overall interval). We compared interval lengths between adults <50 years, 50-74 years, and 75-89 years using multivariable quantile regression.90,225 patients with CRC were included. Of these, 6,853 patients (7.6%) were <50 years. Younger patients were more likely to be female, present emergently, have Stage IV disease, and have rectal cancer compared to middle-aged patients. Factors associated with significantly longer overall intervals included female sex (8.7 days, 95% CI 6.6 to 10.9) and rectal cancer compared to proximal colon cancer (9.8 days, 95% CI 7.4 to 12.2) After adjustment, adults <50 had significantly longer diagnostic intervals (4.3 days, 95% CI 1.3 to 7.3), and significantly shorter treatment intervals (-4.5 days, 95% CI -5.3 to -3.7) compared to middle-aged patients. However, there was no significant difference in the overall interval (-0.6 days, 95% CI -4.3 to 3.2). In stratified models, younger adults with Stage IV disease who presented emergently and patients older than 75 years had longer overall intervals.Younger adults present more often with Stage IV colorectal cancer but have overall similar times from presentation to treatment as screening-eligible older adults.Copyright © 2023 AGA Institute. Published by Elsevier Inc. All rights reserved.