目的: 高催乳素血症被提出在乳腺病变病理生理学中发挥作用。到目前为止，关于高催乳素血症与乳腺病变之间的关系仍有争议。此外，在有乳腺病变人群中高催乳素血症的患病率很少被报道。本研究旨在调查中国绝经前乳腺疾病女性患者中高催乳素血症的患病率，并探讨高催乳素血症与不同临床特征之间的关联。 方法: 本研究是在山东大学齐鲁医院乳腺外科进行的一项回顾性横断面研究。共纳入了2019年1月至2020年12月接受乳腺手术前进行血清催乳素（PRL）水平检测的1,461名女性患者。患者被分为绝经前和绝经后两组。数据使用SPSS 18.0软件进行分析。 结果: 结果显示，1,461名乳腺病变女性患者中有376名（25.74％）血浆催乳素升高。此外，绝经前乳腺疾病患者中高催乳素血症的比例（35.75％，340/951）明显高于绝经后乳腺疾病患者（7.06％，36/510）。在绝经前患者中，诊断为纤维上皮瘤（FETs）和年轻患者（<35岁）的高催乳素血症患病率和平均血清PRL水平显著高于非肿瘤性病变患者和年龄≥35岁的患者（均p <0.05）。尤其是在FETs患者中，催乳素水平呈持续升高的趋势。 结论: 高催乳素血症在中国绝经前乳腺疾病女性患者中普遍存在，特别是在FETs患者中，这暗示着催乳素水平在各种乳腺疾病中可能存在潜在的联系。Copyright © 2023 Zhu, Tang, Lv, Cong, Liu, Zhao, Wang, Zhang, Yu, Cai, Ma and Wang.

Purpose: Hyperprolactinaemia has been proposed to play a role in breast lesions pathophysiology. Thus far, controversial results have been reported for the relationship between hyperprolactinaemia and breast lesions. Moreover, the prevalence of hyperprolactinaemia in a population with breast lesions is scarcely reported. We aimed to investigate the prevalence of hyperprolactinaemia in Chinese premenopausal women with breast diseases, and explore the associations between hyperprolactinaemia with different clinical characteristics. Methods: This was a retrospective cross-sectional study performed in the department of breast surgery of Qilu hospital of Shandong University. Overall, 1,461 female patients who underwent the serum prolactin (PRL) level assay before breast surgery from January 2019 to December 2020 were included. Patients were divided into two groups: before and after menopause. Data were analyzed using SPSS 18.0 software. Results: The results showed an elevated PRL level in 376 of the 1,461 female patients with breast lesions (25.74%). Furthermore, the proportion of hyperprolactinemia among premenopausal patients with breast disease (35.75%, 340/951) was significantly higher than among postmenopausal patients with breast disease (7.06%, 36/510). In premenopausal patients, the proportion of patients with hyperprolactinaemia and the mean serum PRL level were significantly higher in those diagnosed with fibroepithelial tumours (FETs) and in younger patients (aged < 35 years) than in those with non-neoplastic lesions and in those aged ≥ 35 years (both p < 0.05). Especially, the prolactin level exhibited steady ascending tendency for positive correlation with FET. Conclusion: Hyperprolactinaemia is prevalent in Chinese premenopausal patients with breast diseases, especially in those with FETs, which implies a potential association, to some extent, between the PRL levels in various breast diseases.Copyright © 2023 Zhu, Tang, Lv, Cong, Liu, Zhao, Wang, Zhang, Yu, Cai, Ma and Wang.