我们报道了一种新的基于肽的刺球形结构，通过四苯基乙烯-二丝氨酸（TPE-SS）的两步自组装制备而成。在TPE-SS的第一阶段自组装中，通过水凝胶化生成纳米带，这些纳米带在硅晶片上进一步转换成呈现纳米尺度刺的刺球样微结构。水凝胶体中TPE基团的存在导致了汇聚诱导发光特性，在溶液和凝胶相中都表现出来。TPE-SS具有生理pH下β-折叠的TPE端基团水凝胶化剂中最低的分子量。这种新的设计策略似乎对于产生三维自组装微结构和多功能生物材料是有用的。我们发现TPE-SS对人骨髓基质干细胞和乳腺癌细胞是生物相容的，使它们具备在组织工程和生物医学研究中的潜在应用。

We report a new peptide-based urchin-shaped structure prepared through two-step self-assembly of tetraphenylethylene-diserine (TPE-SS). Hydrogelation generated nanobelts through the first stage of self-assembly of TPE-SS; these nanobelts further transformed on silicon wafers into urchin-like microstructures featuring nanosized spines. The presence of the TPE moiety in the hydrogelator resulted in aggregation-induced emission characteristics both in the solution and in the gel phases. TPE-SS has the lowest molecular weight of any TPE-capped hydrogelator with β-sheet-like structures under physiological pH. This new design strategy appears to be useful for generating three-dimensional self-assembled microstructures and multifunctional biomaterials. We found that TPE-SS is biocompatible with human mesenchymal stem cells and breast cancer cells, making them potential applications in tissue engineering and biomedical research.