整合素是一组跨膜受体，连接胞外基质和肌动蛋白骨架，并介导细胞粘附、迁移、信号转导和基因转录。作为双向信号分子，整合素可调节许多肿瘤生成的方面，包括肿瘤生长、侵袭、血管生成、转移和治疗抵抗。因此，整合素具有作为抗肿瘤治疗靶点的巨大潜力。在本综述中，我们总结了近期关于人类肝细胞癌（HCC）中整合素的报道，重点关注癌细胞中整合素的异常表达、激活和信号传导以及在肿瘤微环境中其他细胞的作用。我们还讨论了乙型肝炎病毒相关HCC中整合素的调节和功能。最后，我们更新了整合素相关药物在HCC治疗中的临床和临床前研究。版权所有©2023中国医师协会，由Wolters Kluwer，Inc.根据CC-BY-NC-ND许可生产。

Integrins are a family of transmembrane receptors that connect the extracellular matrix and actin skeleton, which mediate cell adhesion, migration, signal transduction, and gene transcription. As a bi-directional signaling molecule, integrins can modulate many aspects of tumorigenesis, including tumor growth, invasion, angiogenesis, metastasis, and therapeutic resistance. Therefore, integrins have a great potential as antitumor therapeutic targets. In this review, we summarize the recent reports of integrins in human hepatocellular carcinoma (HCC), focusing on their abnormal expression, activation, and signaling of integrins in cancer cells as well as their roles in other cells in the tumor microenvironment. We also discuss the regulation and functions of integrins in hepatitis B virus-related HCC. Finally, we update the clinical and preclinical studies of integrin-related drugs in the treatment of HCC.Copyright © 2023 The Chinese Medical Association, produced by Wolters Kluwer, Inc. under the CC-BY-NC-ND license.