研究动态
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因素相关长期功能和心理社会结局在非霍奇金淋巴瘤患者中。

Factors associated with long-term functional and psychosocial outcomes in patients with non-Hodgkin lymphoma.

发表日期:2023 Feb 28
作者: Bhasker Amatya, Michael Dickinson, Fary Khan
来源: JOURNAL OF REHABILITATION MEDICINE

摘要:

评估一组澳大利亚非霍奇金淋巴瘤(NHL)幸存者的长期功能、心理社会和参与结果。一组横断面成人NHL幸存者在彼得·麦卡洛姆癌症中心(2015年至2020年间)参与了填写经过验证的问卷。一系列分析描述了他们当前的功能水平、心理社会福利和参与状况。共有129名参与者(平均年龄(M)±标准偏差(SD)为62.5±8.8岁),大多数(58%)患有侵袭性NHL和III-IV级(72%),自诊断以来时间为4.6±1.2年。参与者在治疗完成后报告了持续存在的问题:疲劳(63%)、膀胱功能障碍(61%)、认知受损(53%)和NHL相关疼痛(46%)。大多数人在功能上得到了良好的恢复(M±SD)(功能独立度量-运动:79.5±8.2),报告了负面情绪状态和NHL特定生活质量(QoL)的最小变化(癌症治疗功能评估-淋巴瘤:133.5±22.1)。参与者在社区生活中调适良好(社区整合度量:42.2±7.4),对当前的生活感到满意(生活满意度量表:26.3±6.0)。与较差的当前功能水平显著相关的因素是:诊断时年龄<60岁,诊断后时间>4.5年和侵袭性NHL类型。尽管功能恢复良好且适应社区生活,但NHL幸存者报告存在持续的残留障碍和认知问题,需要长期的康复包容性管理。
To assess the long-term functional, psychosocial and participation outcomes in an Australian cohort of non-Hodgkin lymphoma (NHL) survivors.A cross-sectional sample of adult NHL survivors at the Peter MacCallum Cancer Centre (between 2015 and 2020), participated by completing validated questionnaires. A series of analyses described their current level of function, psychosocial well-being, and participation.Of 129 participants (mean (M) ± standard deviation (SD) age: 62.5 ± 8.8 years), the majority (58%) had aggressive NHL and grade III-IV (72%), with time since diagnosis of 4.6 ± 1.2 years. Participants reported ongoing issues after completion of treatment: fatigue (63%), bladder dysfunction (61%), cognitive impairment (53%), and NHL-related pain (46%). Most made good functional recovery (M ± SD) (Functional Independent Measure-Motor: 79.5 ± 8.2), reported minimal change in their negative emotional states, and NHL-specific quality of life (QoL) (Functional Assessment of Cancer Therapy-Lymphoma: 133.5 ± 22.1). Participants were "well" adjusted to community living (Community Integration Measure: 42.2 ± 7.4) and satisfied with their current life (Satisfaction with Life Scale: 26.3 ± 6.0). Factors significantly associated with the poorer current level of function were: age at diagnosis < 60 years, time since NHL diagnosis > 4.5 years, and aggressive NHL type.Despite good functional recovery and adjustment in the community, NHL survivors report the presence of ongoing residual impairments and cognitive issues, which requires long-term rehabilitation-inclusive management.