肺癌中与癌症相关的疲劳：研究议程：美国官方胸腔学会研究声明
Cancer-related Fatigue in Lung Cancer: A Research Agenda: An Official American Thoracic Society Research Statement
影响因子:19.40000
分区:医学1区 Top / 危重病医学1区 呼吸系统1区
发表日期:2023 Mar 01
作者:
Brett C Bade, Saadia A Faiz, Duc M Ha, Miranda Tan, Margaret Barton-Burke, Andrea L Cheville, Carmen P Escalante, David Gozal, Catherine L Granger, Carolyn J Presley, Sheree M Smith, Dawn M Chamberlaine, Jason M Long, Daniel J Malone, William F Pirl, Halley L Robinson, Kazuhiro Yasufuku, M Patricia Rivera
摘要
背景：疲劳是癌症幸存者中最常见的症状。与癌症相关的疲劳（CRF）可能发生在癌症护理连续体的任何时刻。多种因素有助于CRF的发展和严重程度，包括癌症类型，治疗，其他症状，合并症和药物副作用。在临床上，增加体育锻炼，增强睡眠质量以及识别睡眠障碍是管理CRF不可或缺的一部分。不幸的是，尽管与其他癌症相比，尽管肺癌幸存者中的CRF很少经常被识别，评估或治疗。因此，需要提高对CRF的认识和了解，以改善与健康相关的肺癌幸存者生活质量。目标：1）确定和确定知识和研究差距以及2）制定和优先考虑研究问题，以评估肺癌幸存者中CRF的机械，诊断和治疗方法。方法：我们召集了一个多学科小组，以回顾有关CRF的可用文献，重点介绍了体育锻炼，康复和睡眠障碍对肺癌的影响。我们使用三轮修改后的Delphi流程来确定研究问题的优先级。结果：该陈述确定了1）肺癌幸存者中CRF的检测和诊断评估中的知识差距； 2）体育活动和康复的时间，目标和实施； 3）评估和治疗睡眠障碍和疾病以减少CRF。最后，我们提出了该小组最初的32个研究问题和七个最终的优先问题。结论：该声明为1）提高临床和研究工作的优先研究议程，以及2）提高对肺癌幸存者中CRF的认识。
Abstract
Background: Fatigue is the most common symptom among cancer survivors. Cancer-related fatigue (CRF) may occur at any point in the cancer care continuum. Multiple factors contribute to CRF development and severity, including cancer type, treatments, presence of other symptoms, comorbidities, and medication side effects. Clinically, increasing physical activity, enhancing sleep quality, and recognizing sleep disorders are integral to managing CRF. Unfortunately, CRF is infrequently recognized, evaluated, or treated in lung cancer survivors despite more frequent and severe symptoms than in other cancers. Therefore, increased awareness and understanding of CRF are needed to improve health-related quality of life in lung cancer survivors. Objectives: 1) To identify and prioritize knowledge and research gaps and 2) to develop and prioritize research questions to evaluate mechanistic, diagnostic, and therapeutic approaches to CRF among lung cancer survivors. Methods: We convened a multidisciplinary panel to review the available literature on CRF, focusing on the impacts of physical activity, rehabilitation, and sleep disturbances in lung cancer. We used a three-round modified Delphi process to prioritize research questions. Results: This statement identifies knowledge gaps in the 1) detection and diagnostic evaluation of CRF in lung cancer survivors; 2) timing, goals, and implementation of physical activity and rehabilitation; and 3) evaluation and treatment of sleep disturbances and disorders to reduce CRF. Finally, we present the panel's initial 32 research questions and seven final prioritized questions. Conclusions: This statement offers a prioritized research agenda to 1) advance clinical and research efforts and 2) increase awareness of CRF in lung cancer survivors.