猫白血病病毒和猫免疫缺陷病毒感染相关的疾病：一项回顾性研究，共涉及1470只被解剖检查的猫（2010-2020）。
Diseases associated with feline leukemia virus and feline immunodeficiency virus infection: A retrospective study of 1470 necropsied cats (2010-2020).
发表日期：2023 Feb 16
作者：
Lauren Santos de Mello, Paula Reis Ribeiro, Bruno Albuquerque de Almeida, Marcele Bettim Bandinelli, Luciana Sonne, David Driemeier, Saulo Petinatti Pavarini
来源：
Comp Immunol Microb
摘要：
猫白血病病毒（FeLV）和猫免疫缺陷病毒（FIV）是全球范围内影响猫的反转录病毒，感染的普遍性根据地理区域而异。我们对1470只尸检猫的FIV和FeLV相关疾病进行了回顾性描述，其中396只（26.9％）感染了FeLV，199只（13.5％）感染了FIV，134只（9.1％）同时感染了FeLV和FIV。感染FeLV（OR 3.4）和同时感染FeLV和FIV（OR 1.9）的猫更容易患肿瘤。感染FeLV的猫的淋巴瘤和白血病诊断较高（分别为OR 3.9和19.4），同时感染FeLV和FIV的猫的淋巴瘤和白血病诊断也较高（分别为OR 1.9和19.3）。与未感染的猫相比，同时感染FeLV和FIV的猫诊断细菌病的几率更高（OR: 2.8），而感染FeLV的猫诊断病毒病的几率更高（OR: 2.8），其中猫感染传染性腹膜炎的诊断次数增加了2.2倍。受FIV感染的猫的肿瘤和感染性疾病与未感染的猫没有明显差异。根据我们的结果，在巴西南部观察到高普遍性的反转录病毒感染，主要与FeLV相关。感染的猫显著年轻于未感染的猫。与FeLV感染和FeLV和FIV coinfection相关的死亡主要是肿瘤和传染病。相反，FIV感染与任何特定疾病无关。Copyright © 2023 Elsevier Ltd. All rights reserved.
Feline leukemia virus (FeLV) and feline immunodeficiency virus (FIV) are retroviruses affecting cats worldwide, and the prevalence of infection varies considerably according to the geographic area. We retrospectively described FIV- and FeLV-associated diseases in a population of 1470 necropsied cats, of which 396 (26.9%) were infected with FeLV, 199 (13.5%) with FIV, and 134 (9.1%) with FeLV and FIV concomitantly. Cats infected with FeLV (OR 3.4) and co-infected with FeLV and FIV (OR 1.9) were more likely to have neoplasms. The diagnosis of lymphoma and leukemia was higher in cats infected with FeLV (OR 3.9 and 19.4, respectively) and coinfected with FeLV and FIV (OR 1.9 and 19.3, respectively). The odds of diagnosing bacterial diseases were higher in cats coinfected with FeLV and FIV (OR: 2.8), whereas the odds of viral diseases were higher in those infected with FeLV (OR: 2.8), with 2.2 times more diagnoses of feline infectious peritonitis. Neoplastic and infectious diseases in FIV-infected cats did not differ significantly from those in uninfected cats. According to our results, a high prevalence of retroviral infections was observed in southern Brazil, mainly in relation to FeLV. Infected cats were significantly younger than uninfected cats. The main causes of death associated with FeLV infection and FeLV and FIV coinfection were neoplastic and infectious diseases. In contrast, FIV infection was not associated with any specific condition.Copyright © 2023 Elsevier Ltd. All rights reserved.