瞬态电位受体香草素6（TRPV6）钙通道的生物化学和病理生理学
Biochemistry and pathophysiology of the Transient Potential Receptor Vanilloid 6 (TRPV6) calcium channel
影响因子:6.30300
发表日期:2023
作者:
Valerie Walker, Geerten W Vuister
摘要
TRPV6是一种瞬态受体电势香草素（TRPV）阳离子通道，对Ca2离子具有很高的选择性。 1999年首次在寻找介导肠道Ca2吸收的基因时首次确定，其作为细胞内Ca2的监护人的广泛曲目已变得显而易见。对TRPV6缺陷小鼠的研究表明，在胎盘CA2运输，胎儿发育和男性生育能力中表现出了其他重要作用。 2018年出现了关于新生婴儿遗传性不足的第一批报道，揭示了其在人类中的生理重要性。目前有强有力的证据表明，TRPV6也有助于某些常见癌症的发病机理。最近报道的TRPV6缺乏症与非酒精性慢性胰腺炎的关联表明在正常胰腺功能中起作用。随着时间的流逝，随着TRPV6的更高认识，其他疾病缔合可能会出现。强大的分析工具为TRPV6的结构和操作提供了宝贵的见解。它在CA2信号传导和致癌作用中的作用以及在癌症治疗中使用通道抑制剂的作用。这篇综述首先简要描述了通道的生物化学和生理学，以及用于研究这些方法的分析方法。重点随后转移到与异常表达和潜在的病理生理学相关的临床疾病。这篇综述的目的是提高对该渠道的认识，并从广泛的来源中汇集发现，这可能有助于为进一步的研究提出新的想法。
Abstract
TRPV6 is a Transient Receptor Potential Vanilloid (TRPV) cation channel with high selectivity for Ca2+ ions. First identified in 1999 in a search for the gene which mediates intestinal Ca2+ absorption, its far more extensive repertoire as a guardian of intracellular Ca2+ has since become apparent. Studies on TRPV6-deficient mice demonstrated additional important roles in placental Ca2+ transport, fetal bone development and male fertility. The first reports of inherited deficiency in newborn babies appeared in 2018, revealing its physiological importance in humans. There is currently strong evidence that TRPV6 also contributes to the pathogenesis of some common cancers. The recently reported association of TRPV6 deficiency with non-alcoholic chronic pancreatitis suggests a role in normal pancreatic function. Over time and with greater awareness of TRPV6, other disease-associations are likely to emerge. Powerful analytical tools have provided invaluable insights into the structure and operation of TRPV6. Its roles in Ca2+ signaling and carcinogenesis, and the use of channel inhibitors in cancer treatment are being intensively investigated. This review first briefly describes the biochemistry and physiology of the channel, and analytical methods used to investigate these. The focus subsequently shifts to the clinical disorders associated with abnormal expression and the underlying pathophysiology. The aims of this review are to increase awareness of this channel, and to draw together findings from a wide range of sources which may help to formulate new ideas for further studies.