帕金森氏病（PD）是一种常见的神经退行性疾病，其原因是多巴胺能神经元逐渐退化。抑制微胶质细胞的激活可能有助于PD的治疗和预防。Plantamajoside（PMS）是从车前草种子中提取的天然化合物。它具有广泛的生物学活性，包括抗炎、抗氧化以及抗肿瘤作用。然而，它对PD的潜在作用仍不清楚。在这项研究中，首先将脂多糖（LPS）注入C57BL/6雄性小鼠的右中脑黑质（SN）中，建立PD小鼠模型。我们发现，PMS改善了PD小鼠中LPS诱导的行为功能障碍。PMS减轻了PD小鼠中LPS诱导的SN损伤。PMS能够抑制PD小鼠中LPS诱导的微胶质细胞过度活化。此外，MS抑制了PD小鼠及BV-2细胞中LPS诱导的HDAC2/MAPK途径的激活。它进一步揭示了PMS通过抑制HDAC2来缓解微胶质细胞极化。本研究的限制是缺乏进一步的分子机制和体内动物验证实验，需要进一步确认。总的来说，我们的数据表明，PMS可以作为PD的一种有希望的药物。

Parkinson's disease (PD) is a common neurodegenerative disorder caused by dopaminergic neuron progressive degeneration. Inhibition of microglial activation may contribute to the treatment and prevention of PD. Plantamajoside (PMS) is a natural compound extracted from plantain seeds. It has a wide range of biological activities, including anti-inflammatory, antioxidative, as well as antitumor effects. However, its possible effects on PD are still unclear. In this study, lipopolysaccharide (LPS) was first injected into the right midbrain substantia nigra (SN) of male C57BL/6 mice to establish the PD mouse model. We found that PMS improved LPS-induced behavioral dysfunction in PD mice. PMS attenuated LPS-induced SN injury in PD mice. PMS could suppress LPS-induced microglial overactivation in PD mice. In addition, MS inhibited LPS-induced activation of the HDAC2/MAPK pathway in PD mice and BV-2 cells. It further revealed that PMS alleviated microglia polarization by inhibiting HDAC2. The limitation of this study was the lack of experiments for investigating the further molecular mechanism and in vivo animal validation, which needs to be further confirmed in the future. Collectively, our data suggested that PMS could serve as a promising drug for PD.