骨组织工程学 (BTE) 已成为一种充满希望的潜在治疗策略，用于治疗大骨缺陷，包括骨肿瘤、创伤和广泛骨折，这里骨的自愈性不能修复缺陷。骨组织工程由三个主要元素组成：祖细胞/干细胞，支架和生长因子/生化诱导因子。在各种生物材料支架中，由于其生物相容性、可控机械特性、骨导性和骨诱导性能，水凝胶广泛用于骨组织工程。在骨组织工程期间，血管生成在骨重建的成功或失败中发挥着中心作用，通过处理废物并向受伤的微环境提供氧、矿物质、营养物和生长因子。本综述概述了骨组织工程及其要求、水凝胶结构和表征、水凝胶在骨再生中的应用以及水凝胶在骨组织工程期间骨血管生成中的有希望的作用。版权所有 © 2023 刘、杨、刘和高。

Bone tissue engineering (BTE) has become a hopeful potential treatment strategy for large bone defects, including bone tumors, trauma, and extensive fractures, where the self-healing property of bone cannot repair the defect. Bone tissue engineering is composed of three main elements: progenitor/stem cells, scaffold, and growth factors/biochemical cues. Among the various biomaterial scaffolds, hydrogels are broadly used in bone tissue engineering owing to their biocompatibility, controllable mechanical characteristics, osteoconductive, and osteoinductive properties. During bone tissue engineering, angiogenesis plays a central role in the failure or success of bone reconstruction via discarding wastes and providing oxygen, minerals, nutrients, and growth factors to the injured microenvironment. This review presents an overview of bone tissue engineering and its requirements, hydrogel structure and characterization, the applications of hydrogels in bone regeneration, and the promising roles of hydrogels in bone angiogenesis during bone tissue engineering.Copyright © 2023 Liu, Yang, Liu and Gao.