细胞在转移过程中切换不同侵袭方式的能力，也称为侵袭可塑性，是肿瘤细胞的一个重要特征，使它们能够抵抗针对特定侵袭方式的治疗 。由于过渡期间细胞形态的快速变化从间充质到阿米巴状侵袭，可以看出这个过程需要对细胞骨架进行重塑。虽然现已相对详细地描述了细胞侵袭和可塑性的肌动蛋白骨架的作用，但微管的贡献尚未完全阐明。很难推断微管的不稳定是否导致更高的侵袭性，或者相反，因为复杂的微管网络在不同的侵袭方式中发挥不同的作用。虽然间充质迁移通常需要细胞侵入先导缘的微管来稳定突出部分并形成粘附结构，但阿米巴状侵袭即使在缺乏长而稳定的微管的情况下也是可能的，尽管也有阿米巴状细胞的情况，其中微管有助于有效的迁移。此外，微管与其他细胞骨架网络的复杂交互作用也参与侵袭调控。总之，微管在肿瘤细胞可塑性中起重要作用，并因此成为影响细胞增殖和迁移性质的可靶向的因素。 Copyright © 2023 Legátová，Pelantová，Rösel，Brábek和Škarková。

The ability of cells to switch between different invasive modes during metastasis, also known as invasion plasticity, is an important characteristic of tumor cells that makes them able to resist treatment targeted to a particular invasion mode. Due to the rapid changes in cell morphology during the transition between mesenchymal and amoeboid invasion, it is evident that this process requires remodeling of the cytoskeleton. Although the role of the actin cytoskeleton in cell invasion and plasticity is already quite well described, the contribution of microtubules is not yet fully clarified. It is not easy to infer whether destabilization of microtubules leads to higher invasiveness or the opposite since the complex microtubular network acts differently in diverse invasive modes. While mesenchymal migration typically requires microtubules at the leading edge of migrating cells to stabilize protrusions and form adhesive structures, amoeboid invasion is possible even in the absence of long, stable microtubules, albeit there are also cases of amoeboid cells where microtubules contribute to effective migration. Moreover, complex crosstalk of microtubules with other cytoskeletal networks participates in invasion regulation. Altogether, microtubules play an important role in tumor cell plasticity and can be therefore targeted to affect not only cell proliferation but also invasive properties of migrating cells.Copyright © 2023 Legátová, Pelantová, Rösel, Brábek and Škarková.