当代科学家对于肥胖症的普及和其带来的并发症非常清楚，无需“p值”和“相对危险度”等统计数字的支持。现今已经广泛认识到，肥胖与2型糖尿病、高血压、血管疾病、肿瘤和生殖障碍密切相关。肥胖女性显示出更低水平的促性腺激素、受孕率下降、更高的流产率和体外受精结果更差，这表明肥胖会影响女性的生殖能力。此外，脂肪组织包含特殊的免疫细胞，肥胖引发的炎症是一种慢性、低度的炎症反应。在此，我们主要回顾了肥胖对女性生殖全过程的不利影响，包括下丘脑-垂体-卵巢轴、卵子成熟、胚胎和胎儿发育。在后面一部分，我们探讨了肥胖引起的炎症及其对女性生殖相关的表观遗传影响。©作者

Contemporary scientists need no "p value" and "relative risk" statistics to be exquisitely aware of the increasing prevalence of obesity and complications posed by obesity. It is now well recognized that obesity is strongly associated with type 2 diabetes, hypertension, vascular disease, tumors and reproductive disorders. Obese women show lower levels of gonadotropin hormones, reduced fecundity, higher miscarriage rates and poorer outcomes of in vitro fertilization, revealing that obesity affects female reproduction. In addition, adipose tissue contains special immune cells and obesity-induced inflammation is a chronic, low-grade inflammatory response. Herein, we mainly review detrimental influences of obesity in the complete process of female reproduction, including hypothalamic-pituitary-ovarian axis, oocyte maturation, embryo and fetal development. In the latter part, we view obesity-induced inflammation and discuss related epigenetic impact on female reproduction.© The author(s).