本文回顾了动物模型中光动力疗法（PDT）在乳腺癌（BC）中的应用。这些体内模型模拟了肿瘤的进展，帮助诊断，并为新药的批准过程中的治疗评估提供机会。BC在女性癌症中名列第一。现如今，对于BC有许多诊断方法和治疗选择，但大部分都有严重的副作用。本文讨论了使用小型和大型动物模型进行BC模型研究的优缺点。文献回顾表明，大多数研究使用了大型动物模型，近年来越来越多的人对小型动物模型中BC的研究产生了兴趣。MCF-7、BT-474、MDA-MB-231和4T1等BC细胞系在二维和三维体外细胞培养和皮下模型中是商业可得的。本文旨在讨论PDT在动物模型中的表现及其进一步的临床意义。PDT被认为是一种非侵入性疗法，它利用单色光和能量激发光敏剂（PSs），生成所需的活性氧物质。在这篇文章中，我们讨论了在BC模型中使用的五种光敏剂，如叶绿素e6（Ce6）、亚甲蓝、吲哚菁绿、5-氨基乙酸和间-四(羟基苯基)菁。我们在PubMed和Scopus数据库中搜索了关键词：“光动力疗法”、“乳腺癌”、“动物模型”、“临床研究”和“光敏剂”。PDT在动物实验中的研究结果及其对活体的影响表明，其在局部和弥散性BC患者的临床试验中有应用的可能性。小型和大型BC动物模型的可得性和可访问性促进了癌症药物创新技术和新诊断和治疗方法的进展和试验。© 2023 The Author(s). Published by IMR Press.

In this article, we reviewed the use of photodynamic therapy (PDT) for breast cancer (BC) in animal models. These in vivo models imitate the cancer disease progression, aid diagnosis, as well as create opportunities to assess treatment during the approval process for the new drug. BC ranks first among women's cancers. Nowadays, there are many diagnostic methods and therapy options for BC but the majority of them have severe side effects. This article discusses the advantages and some disadvantages of the use of small and large animals used for BC models. A literature review showed that the majority of studies have used large animal models, and recently there has been more interest in developing BC in small animal models. BC cell lines such as MCF-7, BT-474, MDA-MB-231, and 4T1 are commercially available for two-dimensional and three-dimensional in vitro cell cultures and subcutaneous models. The purpose of this article is to discuss the performance of PDT in animal models and its further clinical implications. PDT is known to be a non-invasive therapy, which uses monochromatic light and energy to excite photosensitizers (PSs) for the generation of reactive oxygen species as the required factors. Herein, we discuss the use of five photosensitizers in BC models such as chlorin e6 (Ce6), methylene blue, indocyanine green, 5-aminolevulinic acid, and meta-tetra(hydroxyphenyl)chlorin. The database PubMed and Scopus were searched for keywords: 'photodynamic therapy', 'breast cancer', 'animal model', 'clinical studies', and 'photosensitizer(s)'. The PDT search results in animal experiments and its effect on a living organism indicate the possibility of its application in clinical trials on women with local and disseminated BC. The availability and accessibility of small and large BC animal models enable the progress and trial of cancer drugs for innovative technologies and new diagnostics and treatments.© 2023 The Author(s). Published by IMR Press.