由于软组织肉瘤（STS）的亚型众多且肿瘤生物学具有侵袭性，这给医生带来了许多挑战。目前在如何频繁进行手术后的监测扫描上，对于这些肿瘤尚无一致的管理策略，这引发了持续的辩论。然而，多学科治疗的进步在近年来改善了患者的预后。对局部复发的早期检测反映了一种更具侵袭性的肿瘤，即使是与相同组织病理学实体相关。治疗四肢软组织肉瘤的局部复发是一个困难的临床挑战。目标应该是在可能的情况下保留肢体，采用切除和放疗等治疗手段，尽管在某些情况下可能需要截肢。局部治疗，如高强度低剂量治疗或白细胞介素-1受体拮抗剂治疗，是针对疾病复发位置而提供的令人满意的治疗选项，无论是作为决定性治疗还是辅助治疗。迟发性复发后生存率较高可通过肿瘤生物学的变化解释。由于高级别的软组织肉瘤患者的长期生存率实际上较差，这就需要实施积极的监测方法。

Patients diagnosed with soft tissue sarcoma (STS) present a number of challenges for physicians, due to the vast array of subtypes and aggressive tumor biology. There is currently no agreed-upon management strategy for these tumors, which has led to the ongoing debate surrounding how frequently surveillance scans should be performed following surgery. However, advances in multidisciplinary care have improved patient outcomes over recent years. The early detection of local recurrence reflects a more aggressive tumor, even in association with the same histopathologic entity. Treating the local recurrence of extremity STS is a difficult clinical challenge. The goal should be to salvage limbs when possible, with treatments such as resection and irradiation, although amputation may be necessary in some cases. Regional therapies such as high-intensity, low-dose or interleukin-1 receptor antagonist treatment are appealing options for either definitive or adjuvant therapy, depending on the location of the disease's recurrence. The higher survival rate following late recurrence may be explained by variations in tumor biology. Since long-term survival is, in fact, inferior in patients with high-grade STS, this necessitates the implementation of an active surveillance approach.