PI3K/Akt/mTOR通路调节细胞生长、增殖、代谢和运动。此外，重要研究表明，与该通路相关的基因在人类癌症中频繁活化。观察及计算建模已在临床试验中对PI3K/Akt/mTOR通路抑制剂进行研究。观察到来自临床研究和多种抑制剂的有效性和安全性证据已获得了FDA批准。在本综述文章中，我们重点关注PI3K/Akt/mTOR信号通路在癌症中过度活化的过程，并提供了PI3K/Akt/mTOR抑制剂作为单一药物或不同剂量药物组合对不同类型癌症的概述。此外，本文讨论了PI3K/Akt/mTOR信号通路的生物学功能和激活，以及其在癌症发展中的作用。另外，我们讨论了PI3K/Akt/mTOR抑制剂开发中的潜在挑战和相应的预测反应和耐药性生物标志物。本文重点关注使用PI3K/Akt/mTOR通路来靶向特定分子的最新突破。版权所有© Bentham Science Publishers，请发送任何查询至epub@benthamscience.net。

The PI3K/Akt/mTOR pathway modulates cell growth, proliferation, metabolism, and movement. Moreover, significant studies have shown that the genes involved in this pathway are frequently activated in human cancer. Observational and computational modeling of the PI3K/AKt/mTOR pathway inhibitors has been explored in clinical trials. It has been observed that the effectiveness and safety evidence from clinical studies and various inhibitors of this route have been given FDA approval. In this review article, we focused on the processes behind the overactivation of PI3K/Akt/mTOR signaling in cancer and provided an overview of PI3K/Akt/mTOR inhibitors as either individual drugs or a combination of different doses of drugs for different types of cancer. Furthermore, the review discusses the biological function and activation of the PI3K/AKt/mTOR signaling and their role in the development of cancers. Additionally, we discussed the potential challenges and corresponding prediction biomarkers of response and resistance for PI3K/Akt/mTOR inhibitor development. The article focuses on the most current breakthroughs in using the PI3K/Akt/mTOR pathway to target certain molecules.Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.