以FAP为靶点的纳米药物传递系统用于口腔白斑的综合治疗。
Nano-drug delivery system targeting FAP for the combined treatment of oral leukoplakia.
发表日期：2023 Aug 01
作者：
Ran Li, Yingjiao Zhao, Tiantian Liu, Yanwei Li, Chaoqiong Wan, Ruifang Gao, Chen Liu, Xianqi Li, Bing Li
来源：
Cellular & Molecular Immunology
摘要：
口腔白斑（OLK）因其潜在的恶性转化风险而受到广泛关注。研究表明，当药物治疗与光热疗法（PTT）结合时，不仅可以增强药物的细胞毒性，还可以利用热能杀死病变细胞，因此我们可以将药物治疗与PTT结合以增强对OLK的治疗效果。然而，由于缺乏靶向性，成纤维细胞活化蛋白（FAP）已成为OLK联合治疗的一个有吸引力的靶标。在本研究中，我们利用负载有FAP靶向肽（F-TP）和Celecoxib（CXB）的NGO-PEG构建了一个纳米药物传递系统CGPF，以靶向表达FAP较高的OLK，并通过体外和体内实验证实了CGPF的生物相容性和治疗效果。总体而言，本研究提出的新型纳米药物传递系统CGPF对于OLK的联合治疗具有非常显著的潜力。© 2023. 控释学会（CRS）。
Oral leukoplakia (OLK) has received much attention due to its potential risk of malignant transformation. Studies have shown that when drug therapy is combined with photothermal therapy (PTT), not only can the cytotoxicity of the drug be enhanced, but also the heat energy can be used to kill the lesion cells, so we can combine drug therapy with PTT to enhance the therapeutic effect on OLK. However, with certain drawbacks due to its lack of targeting, fibroblast activating protein (FAP) has become an attractive target for OLK combination therapy. In this study, we used NGO-PEG loaded with FAP-targeting peptide (F-TP) and celecoxib (CXB) to construct a nano-drug delivery system CGPF for targeting OLK with high FAP expression and confirmed the biocompatibility and therapeutic efficacy of CGPF by in vitro and in vivo experiments. Overall, the novel nano-drug delivery system CGPF proposed in this study showed a very significant potential for the combination therapy of OLK.© 2023. Controlled Release Society.