锐齿委陵菜（Potentilla rugulosa Nakai）是蔷薇科(Rosaceae)的多年生草本植物，分布于韩国的山区。我们先前的研究发现锐齿委陵菜富含多种多酚和黄酮类化合物，具有重要的抗氧化和抗肥胖生物活性。双酚A（Bisphenol A，BPA）是一种外源雌激素，已被证实在人体中引起肺部炎症。然而，BPA引起炎症的机制尚未确定。本研究旨在考察锐齿委陵菜乙醇提取物对BPA引起的炎症是否具有抑制作用，并利用一种腺癌人肺泡基底上皮细胞系A549进行研究。锐齿委陵菜提取物通过减少活性氧（ROS）水平，抑制BPA介导的细胞毒性。此外，锐齿委陵菜提取物抑制了核因子κ-B（NF-κB）和丝裂原活化蛋白激酶（MAPK）信号通路激活所诱导的多种促炎介质的上调。NF-κB和MAPK信号通路的抑制作用通过减少NF-κB的转录活性来实现。此外，我们观察到锐齿委陵菜提取物阻断了细胞外信号调节激酶1/2（ERK1/2）和应激活化蛋白激酶/JUN N端激酶（SAPK/JNK）的磷酸化。因此，我们的研究结果表明，锐齿委陵菜乙醇提取物可能作为一种天然抗炎治疗药物。

Potentilla rugulosa Nakai (P. rugulosa) is a perennial herb in the Rosaceae family and found in the Korean mountains. Previously, our findings demonstrated that P. rugulosa contains numerous polyphenols and flavonoids exhibiting important antioxidant and anti-obesity bioactivities. Bisphenol A (BPA) is a xenoestrogen that was shown to produce pulmonary inflammation in humans. However, the mechanisms underlying BPA-induced inflammation remain to be determined. The aim of this study was to examine whether ethanolic extract of P. rugulosa exerted an inhibitory effect on BPA-induced inflammation utilizing an adenocarcinoma human alveolar basal epithelial cell line A549. The P. rugulosa extract inhibited BPA-mediated cytotoxicity by reducing levels of reactive oxygen species (ROS). Further, P. rugulosa extract suppressed the upregulation of various pro-inflammatory mediators induced by activation of the nuclear factor kappa-light-chain-enhancer of activated B cell (NF-κB) and mitogen-activated protein kinase (MAPK) signaling pathways. In addition, inhibition of the NF-κB and MAPK signaling pathways by P. rugulosa extract was found to occur via decrease in the transcriptional activity of NF-κB. Further, blockade of phosphorylation of extracellular signal-regulated kinase 1/2 (ERK1/2) and stress-activated protein kinase/Jun N-terminal kinase (SAPK/JNK) was noted. Thus, our findings suggest that the ethanolic extract of P. rugulosa may act as a natural anti-inflammatory therapeutic agent.