基于核酸修饰的疾病诊断。
Disease Diagnosis Based on Nucleic Acid Modifications.
发表日期：2023 Aug 01
作者：
Xiaochen Xue, Zhiying Wang, Yafen Wang, Xiang Zhou
来源：
Epigenetics & Chromatin
摘要：
核酸修饰包括广泛的表观遗传和表观转录因子，由于它们对生物遗传、生长和代谢的深远影响，影响了广泛的核酸。最近发展起来的核酸修饰定位和特征化方法促进了它们的发现以及在真核生物，特别是在人类中的大规模研究。由于这些开创性的策略，核酸修饰被证实对癌症等人类疾病有巨大影响。因此，核酸修饰是否能成为一种新型生物标志物仍是一个悬而未决的问题。本综述简要回顾经典的核酸修饰，然后着重介绍研究这些修饰作为临床治疗的诊断生物标志物取得的进展，并提出我们对其发展前景的看法。
Nucleic acid modifications include a wide range of epigenetic and epitranscriptomic factors and impact a wide range of nucleic acids due to their profound influence on biological inheritance, growth, and metabolism. The recently developed methods of mapping and characterizing these modifications have promoted their discovery as well as large-scale studies in eukaryotes, especially in humans. Because of these pioneering strategies, nucleic acid modifications have been shown to have a great impact on human disorders such as cancer. Therefore, whether nucleic acid modifications could become a new type of biomarker remains an open question. In this review, we briefly look back at classical nucleic acid modifications and then focus on the progress made in investigating these modifications as diagnostic biomarkers in clinical therapy and present our perspective on their development prospects.