真菌组的：与宿主的相互作用及其在疾病中的影响。
The mycobiome: interactions with host and implications in diseases.
发表日期：2023 Jul 30
作者：
Yani Fan, Lijuan Wu, Bing Zhai
来源：
CURRENT OPINION IN MICROBIOLOGY
摘要：
在过去的十年里，我们对人类黏膜表面相关真菌群落（即真菌组）的组成和功能的理解迅速扩展。真菌在出生时就在黏膜表面的不同部位进行定植，并在成年期间对免疫系统的发育和稳态起重要作用。本文综述了人类真菌组在不同部位的最新研究进展，包括胃肠道、呼吸道、泌尿生殖道、口腔、皮肤表面和肿瘤组织。研究人员在表征真菌组与免疫系统之间的相互作用方面进行了广泛努力，尤其是在胃肠道方面。我们讨论了真菌组菌群失调及其对疾病进展的影响，如炎症性肠病、酒精性肝病、全身性感染、癌症等，并指出真菌组靶向干预策略在治疗威胁生命的疾病中的潜力。版权所有© 2023 The Authors。由Elsevier Ltd.出版。保留所有权利。
Over the past decade, our understanding of the composition and function of the human mucosal surface-associated fungal community (i.e. the mycobiome) has rapidly expanded. Fungi colonize at various sites of the mucosal surface at birth and play important roles in the development and homeostasis of immune system throughout adulthood. Here, we review the recent research progresses in the human mycobiome at different body sites, including the gastrointestinal (GI) tract, the respiratory tract, the urogenital tract, the oral cavity, the skin surface, and the tumor tissues. Researchers have made extensive effort in characterizing the interactions between mycobiome and immune system, especially in the GI tract. We discuss the mycobiome dysbiosis and its implications to the progression of diseases such as inflammatory bowel diseases, alcoholic liver diseases, systemic infections, cancers, and so on, indicating the potential of mycobiome-targeting intervention strategy for life-threatening diseases.Copyright © 2023 The Authors. Published by Elsevier Ltd.. All rights reserved.