用于疾病建模的由人类多能和成体干细胞分化得来的肾器官类结构
Kidney Organoid Derived from Human Pluripotent and Adult Stem Cells for Disease Modeling.
发表日期：2023 Jun
作者：
Hyun Mi Kang
来源：
Stem Cell Research & Therapy
摘要：
肾脏疾病影响了全球人口的相当大比例，然而尽管在识别遗传原因方面取得了进展，有效的治疗仍然缺乏。这一局限性可以归因于缺乏准确模拟人类肾脏疾病的适当体外模型，从而阻碍了有针对性的治疗开发。然而，人类诱导多能干细胞 (PSCs) 的出现以及利用它们发展出的器官样体为在人体中模拟肾脏发育和疾病的研究提供了一种途径，同时也能验证新药物的效果。为了充分发挥器官样体在这些领域的能力，对于肾脏器官样体来说，密切地模拟成人肾脏的结构和功能至关重要。在本综述中，我们将讨论使用人类PSCs或成人肾脏干细胞衍生的肾脏器官样体模拟遗传性肾脏疾病和肾癌的潜力。© Copyright 2023 The Korean Society of Developmental Biology.
Kidney disease affects a significant portion of the global population, yet effective therapies are lacking despite advancements in identifying genetic causes. This limitation can be attributed to the absence of adequate in vitro models that accurately mimic human kidney disease, hindering targeted therapeutic development. However, the emergence of human induced pluripotent stem cells (PSCs) and the development of organoids using them have opened up a way to model kidney development and disease in humans, as well as validate the effects of new drugs. To fully leverage their capabilities in these fields, it is crucial for kidney organoids to closely resemble the structure and functionality of adult human kidneys. In this review, we aim to discuss the potential of using human PSCs or adult kidney stem cell-derived kidney organoids to model genetic kidney disease and renal cancer.© Copyright 2023 The Korean Society of Developmental Biology.