子宫颈癌的现场诊断：宫颈阴道液中潜在的蛋白质标志物。
Point-of-care diagnosis of cervical cancer: potential protein biomarkers in cervicovaginal fluid.
发表日期：2022
作者：
Büşra Köse, Özgüç Takmaz, Mete Güngör, Ahmet Tarık Baykal
来源：
BIOSENSORS & BIOELECTRONICS
摘要：
宫颈癌（CxCa）可通过疫苗接种和筛查来预防和治疗。宫颈阴道液（CVF）代表女性生殖道的生理成分。这些成分适合用于临床用途，因此使CVF成为一种适合疾病筛查方法的材料。由于目前昂贵的常规CxCa筛查方法存在高假阴性结果率和低就诊率，开发一种全球每位女性都能接触到的现场筛查方法变得更加重要。为此，已开发出多种用于人乳头瘤病毒（HPV）感染筛查的自用设备。此外，由于HPV测试的低特异性和HPV感染的高清除率，许多患者接受了过度治疗。由于蛋白质在细胞过程和癌变中起重要作用，因此使用蛋白质进行简单的筛查测试来检测癌变是恰当的。本文将概述现场筛查测试和发现CVF蛋白质生物标志物的研究，以考虑开发一种可用于快速和可行的CxCa筛查方法的方法。 © TÜBİTAK.
Cervical cancer (CxCa) is preventable and treatable via vaccination and screening. Cervicovaginal fluid (CVF) represents the physiological components of the female genital tract. These components are suitable to be utilized for clinical purposes, therefore, making CVF a suitable material for disease screening approaches. Due to high false-negative result rates and low attendance of current expensive routine CxCa screening methods, it has become more important to develop a point-of-care (POC) screening method that every single woman could reach worldwide. For this purpose, various self-usage apparatus have been developed for screening of the human papilloma virus (HPV) infection. Furthermore, due to the low specificity of HPV tests and the high clearance rate of HPV infections, many patients undergo overtreatment. Since proteins play an important role in cellular process and carcinogenesis, it is appropriate to use proteins in a simple screening test for the detection of carcinogenesis. In this article, POC screening tests and the studies of discovery of CVF protein biomarkers will be overviewed to consider the development of a method that can be used for the rapid and conceivable screening method of CxCa.© TÜBİTAK.