恶性高钙血症：一种后可逆性脑病综合征的罕见病因。
Malignant Hypercalcemia: A Rare Etiology of Posterior Reversible Encephalopathy Syndrome.
发表日期：2023 Jun
作者：
Victor A Odoma, Iman Zahedi, Hassan Haq, Stefany C Lopez Pantoja, Ezrah C Onyejide, Farzana Rahman
来源：
Brain Structure & Function
摘要：
后可逆性脑白质病(PRES)是一种罕见且严重的神经毒性脑病状态，其神经表现多样，包括头痛、混乱、癫痫发作、昏迷以及可在影像学上显示为可逆的皮层下脑血管源性水肿。PRES通常是由慢性肾功能衰竭、高血压、化疗药物和子痫引起的。由高钙血症引起的PRES较少见，并未广泛受到文献关注。我们报道了一例 61 岁女性患者，诊断为晚期乳腺癌，出现知觉改变和全身肢体无力。经检查发现患者出现恶性高钙血症，并且脑成像显示枕叶和额叶皮质下存在脑血管源性水肿，提示了PRES的可能。治疗高钙血症后，患者的病情逐渐好转。版权所有 © 2023, Odoma等。
Posterior reversible encephalopathy syndrome (PRES) is a rare and severe neurotoxic encephalopathic state characterized by variable neurologic manifestations ranging from headache and confusion to seizures, coma, and reversible subcortical vasogenic edema on imaging. PRES is commonly induced by chronic renal failure, hypertension, chemotherapeutic drugs, and eclampsia. PRES induced by hypercalcemia is uncommon and not widely underlined in the literature. We underline a case of a 61-year-old female diagnosed with advanced breast carcinoma presented with altered sensorium and generalized limb weakness. She was found to have malignant hypercalcemia, and brain imaging demonstrated subcortical vasogenic edema in the occipital and frontal lobe, suggestive of PRES. Her condition gradually improved after the treatment of hypercalcemia.Copyright © 2023, Odoma et al.