肥胖是一个与心理健康有关的全球性健康问题。阐明与炎症和氧化应激有可能重叠的生化机制对于更好地理解和解决肥胖和相关代谢性疾病至关重要。本研究旨在调查希腊代谢不良肥胖队列中炎症和氧化应激指标与代谢、情绪和心理健康反映参数之间的关联。共招募了122名代谢不良的肥胖人群进行调查。评估了人体测量、生化、炎症和氧化应激标记物。通过失眠、自尊心、抑郁、身体和心理健康方面的问卷评估了生活质量。炎症生物标志物肿瘤坏死因子-α（TNF-α）和氧化低密度脂蛋白/低密度脂蛋白比率（oxLDL/LDL）在高血压（p=0.002，p=0.001）和高血糖患者（p=0.017，p=0.001）中较高。此外，TNF-α（p<0.001），oxLDL/LDL（p<0.001）和oxLDL/高密度脂蛋白（HDL）（p=0.016）与代谢综合征成分的增加显著增加。最后，发现白细胞介素-6（IL-6）与Rosenberg自尊心量表之间存在负相关（Beta=-0.019，p=0.019），TNF-α与修订版流行病学研究中心抑郁量表之间存在正相关（Beta=0.003，p=0.015）。研究结果表明，与肥胖相关的全身性炎症与较差的自尊心和抑郁症状有关，这表明存在重叠的机制，可用于肥胖管理。© 2023 Amerikanou, Valsamidou, Kleftaki, Gioxari, Koutoulogenis, Aroutiounova, Stergiou and Kaliora.

Obesity is a significant worldwide health problem that is linked with mental health. The elucidation of the possible overlapping biochemical mechanism(s) involved in inflammation and oxidative stress is imperative to better understand and address obesity and related metabolic disorders. The aim of the study was to investigate the associations between inflammatory and oxidative stress profiles with parameters that reflect metabolic, emotional, and mental health in a Greek metabolically unhealthy obese cohort.In total, 122 metabolically unhealthy people with obesity were recruited. Anthropometric measurements, biochemical, inflammatory and oxidative stress markers were assessed. Quality of life was evaluated through questionnaires for insomnia, self-esteem, depression, physical and mental health.The inflammatory biomarker tumor necrosis factor-alpha (TNF-α) and the ratio oxidized low-density lipoprotein/low-density lipoprotein (oxLDL/LDL) were higher in hypertensive (p=0.002, p=0.001 respectively) and hyperglycemic subjects (p=0.017, p=0.001 respectively). Furthermore TNF-α (p<0.001), oxLDL/LDL (p<0.001) and oxLDL/high-density lipoprotein (HDL) (p=0.016) increased significantly with the increase of metabolic syndrome components. Finally, a negative association between interleukin-6 (IL-6) and Rosenberg Self-Esteem Scale (Beta=-0.019, p=0.019) and a positive association between TNF-α and the Center for Epidemiologic Studies Depression Scale Revised (Beta=0.003, p=0.015) were found.The results of the study suggest that obesity-related systemic inflammation is associated with worse self-esteem and depression symptoms, indicating an overlapping mechanism which can be utilized to the management of obesity.Copyright © 2023 Amerikanou, Valsamidou, Kleftaki, Gioxari, Koutoulogenis, Aroutiounova, Stergiou and Kaliora.