最近，存在性被提出作为连续爆发神经元用来调节稳定输出的离子通道mRNA关系的主要反馈机制。然而，某些神经元类型只在间歇性活动期间存在，并且可能需要诱导和限制不同活动状态下适当离子通道配置的其他机制。为了解决这个问题，我们使用了甲壳动物美洲大螯虾胃运动神经节中的腹胃部舌骨膨大肌（PD；持续激活）和侧胃（LG；短暂激活）神经元。我们通过实验性刺激到神经节的下行输入来释放已知能够引发LG神经元活动状态的神经调节物质，并在活跃和沉默的LG神经元中量化了11个电压门控离子通道的mRNA丰度和成对关系。相同的刺激对PD活动并没有引起显著改变。LG的激活上调了离子通道mRNA和正相关的离子通道mRNA关系的数量。相反，这种刺激并没有引发PD细胞离子通道mRNA丰度和关系的主要变化，表明它们的持续活动足以在改变的调节条件下维持离子通道mRNA关系。此外，我们发现由LG的活动状态诱导的离子通道mRNA相关性受到活动和神经调节物依赖的反馈机制的影响。有趣的是，PD中的一些相同相关性通过不同的机制保持，这表明这些运动网络利用不同的反馈机制来协调不同神经元类型间相同的mRNA关系。

Recently, activity has been proposed as a primary feedback mechanism used by continuously bursting neurons to coordinate ion channel mRNA relationships that underlie stable output. However, some neuron types only have intermittent periods of activity and so may require alternative mechanisms that induce and constrain the appropriate ion channel profile in different states of activity. To address this, we used the pyloric dilator (PD; constitutively active) and the lateral gastric (LG; transiently active) neurons of the stomatogastric ganglion (STG) of the crustacean Cancer borealis. We experimentally stimulated descending inputs to the STG to cause release of neuromodulators known to elicit the active state of LG neurons and quantified the mRNA abundances and pairwise relationships of 11 voltage gated ion channels in active and silent LGs. The same stimulus does not significantly alter PD activity. Activation of LG up-regulated ion channel mRNAs and lead to a greater number of positively correlated pairwise channel mRNA relationships. Conversely, this stimulus did not induce major changes in ion channel mRNA abundances and relationships of PD cells, suggesting their ongoing activity is sufficient to maintain channel mRNA relationships even under changing modulatory conditions. Additionally, we found that ion channel mRNA correlations induced by the active state of LG are influenced by a combination of activity- and neuromodulator-dependent feedback mechanisms. Interestingly, some of these same correlations are maintained by distinct mechanisms in PD, suggesting that these motor networks utilize distinct feedback mechanisms to coordinate the same mRNA relationships across neuron types.