胰腺导管腺癌（PDAC）是癌症相关死亡的主要原因之一。酪氨酸激酶受体（TKR）负责细胞可塑性、耐药性、免疫抑制和转移潜力。Axl是TKR家族的受体，在过去十年中在癌症治疗中备受关注。本研究旨在研究免疫组织化学Axl表达与PDAC组织学特征的关系以及其在预后中的重要性。 对2006年至2017年接受PDAC手术的53位患者进行了回顾性评估。记录了肿瘤的特征，包括大小、淋巴血管浸润（LVI）、神经外侵（PNI）、切缘（RM）、淋巴结转移（LNM）、分化程度、肿瘤浸润淋巴细胞、分期和总生存期。通过免疫组织化学方法，膜和/或细胞质染色被认为是Axl阳性。统计学上使用SPSS 21.0程序中的Pearson卡方、Cox回归和Kaplan-Meier测试。 28例患者（52.8%）Axl呈阳性。发现Axl阳性与LVI的存在（P = 0.009）和LNM（P = 0.002）相关，并且是短期生存的独立预后因素（P = 0.006）。 研究发现，在PDAC的致癌过程中，Axl的表达增加可以增加EMT介导的转移，可能是PDAC患者局部扩散和恶预后的指标。在这方面，它可以作为PDAC患者个体化治疗中有希望的靶向分子。

Pancreas Ductal Adenocarcinomas (PDACs) are among the leading causes of cancer-related death. Tyrosine kinase receptors (TKRs) are responsible for cell plasticity, chemoresistance, immunosuppression and metastasis potential. Axl is a receptor of the TKR family, and it has come to the fore in cancer treatment in the last decade. This study aimed to investigate the relationship of immunohistochemical Axl expression with histological features and its prognostic importance in PDACs.Fifty-three patients who were operated on for PDAC between 2006-2017 were evaluated retrospectively. Features of tumors; size, lymphovascular invasion (LVI), perineural invasion (PNI), resection margin (RM), lymph node metastasis (LNM), differentiation, tumor-infiltrating lymphocyte, stage and overall survival were recorded. Immunohistochemically, membranous and or cytoplasmic staining was considered positive for Axl. Statistically, Pearson Chi-Square, Cox regression and Kaplan Mayer tests were used in the SPSS 21.0 program.Axl was positive in 28 patients (52.8%). Axl positivity was found to be associated with the presence of LVI (P = 0.009) and LNM (P = 0.002) and was an independent prognostic factor in short survival (P = 0.006).It was found that increased expression of Axl, which is known to increase EMT-mediated metastasis in carcinogenesis, may be an indicator of local spread and poor prognosis in PDAC patients. In this respect, it can be promising as a targeted molecule in PDAC patient's individualized treatments.