OSCC的恶劣伴侣：白色念珠菌。
The evil companion of OSCC: Candida albicans.
发表日期：2023 Aug 02
作者：
Zhixin Yang, Shiyu Zhang, Ning Ji, Jing Li, Qianming Chen
来源：
ORAL DISEASES
摘要：
微生物菌群失调和微生物菌群诱导的炎症可能在口腔鳞状细胞癌（OSCC）的病因病理机制中起到了一定的作用。白色念珠菌（Candida albicans）是口腔腔内最常见的机会性致病真菌，念珠菌感染被认为是其高风险因素之一。虽然口腔微生物群与宿主的相互作用与OSCC的发展密切相关，但真菌与OSCC之间的相互关系与细菌和病毒之间的相互关系相比尚不清楚。本文累积了关于C. albicans促进OSCC恶性转化的证据、病原因素和可能的多种机制的知识，重点关注了上皮损伤的诱导、致癌物质的产生和肿瘤微环境的调节。此外，我们还强调了最新的白色念珠菌感染治疗策略。本综述为C. albicans和OSCC之间的相互关系提供了新的视角，并有助于建立一个系统性和可靠的临床治疗体系，用于治疗C. albicans感染的OSCC患者。© 2023 Wiley Periodicals LLC.
Microbial dysbiosis and microbiome-induced inflammation may play a role in the etiopathogenesis of oral squamous cell carcinoma (OSCC). Candida albicans (C. albicans) is the most prevalent opportunistic pathogenic fungus in the oral cavity, and Candida infection is considered as one of its high-risk factors. Although oral microbiota-host interactions are closely associated with the development of OSCC, the interrelationship between fungi and OSCC is poorly understood compared to that between bacteria and viruses.We accumulated knowledge of the evidence, pathogenic factors, and possible multiple mechanisms by which C. albicans promotes malignant transformation of OSCC, focusing on the induction of epithelial damage, production of carcinogens, and regulation of the tumor microenvironment. In addition, we highlight the latest treatment strategies for Candida infection.This review provides a new perspective on the interrelationship between C. albicans and OSCC and contributes to the establishment of a systematic and reliable clinical treatment system for OSCC patients with C. albicans infection.© 2023 Wiley Periodicals LLC.