近年来，激光作为医学领域的潜在治疗选择已引起相当大的关注。其中，光热疗法被作为一种利用光热效应来移除肿瘤组织的技术进行研究。该方法通过提高肿瘤组织的温度来摧毁它，主要研究用于皮肤癌治疗。本研究旨在通过数值模拟模型模拟具有鳞状细胞癌的皮肤层，并研究在不同数量血管的条件下，如变化的激光强度和金纳米颗粒体积分数，介质中的温度分布的影响。采用离散偶极子近似方法计算了光吸收增强剂的光学性质，并使用连续、动量和能量方程计算了温度和速度分布。对每种情况进行了凋亡变量的定量测定，以评估治疗效果，并确定了具有最大治疗效果的治疗条件。根据血管数量的不同，确定了具有最佳治疗效果的激光强度分别为0.13 W、0.15 W、0.18 W和0.24 W，注射的金纳米棒体积分数对所有血管数量都确定为10-6。本研究的结果可作为未来进行光热疗法时选择适当治疗条件的指南。版权所有 © 2023 Elsevier B.V. 发布。

In recent years, lasers have gained considerable attention as a potential treatment option in the medical field. Photothermal therapy, in particular, has been investigated as a technique to remove tumor tissue by leveraging photothermal effects. The method involves raising the temperature of the tumor tissue to destroy it and has primarily been studied for skin cancer treatment.This study aimed to simulate a skin layer with squamous cell carcinoma by using numerical modeling and investigate the effect of different numbers of blood vessels on the temperature distribution in the medium under conditions such as varied laser intensity and gold nanoparticle volume fraction.Optical properties of the light absorption enhancer were calculated using the discrete dipole approximation method, and the temperature and velocity distribution were computed using continuity, momentum, and energy equations.Quantitative determination of the apoptotic variable was performed to evaluate the treatment effect for each case, and the treatment condition with the maximum treatment effect was identified. Laser intensity with optimal therapeutic effect was confirmed to be 0.13 W, 0.15 W, 0.18 W, and 0.24 W, depending on the number of vessels, respectively, and the volume fraction of injected GNRs was confirmed to be 10-6 for all vessel numbers.The results of this study can serve as a guide for selecting appropriate treatment conditions when conducting photothermal therapy in the future.Copyright © 2023. Published by Elsevier B.V.