冷等离子体在治疗类风湿性关节炎增殖性滑膜炎中的潜在物理疗法。
Cold atmospheric pressure plasma: A potential physical therapy for rheumatoid arthritis hyperplastic synovium.
发表日期：2023 Jul 31
作者：
Chengbiao Ding, Qi Liu, Wenchong Ouyang, Yichen Sun, Quan Liu, Shuzhan Gao, Zhengwei Wu
来源：
INTERNATIONAL IMMUNOPHARMACOLOGY
摘要：
类风湿性关节炎（RA）最重要的病理变化是关节内滑膜增生。滑膜增生引起的一系列降解性酶和氧化应激导致类风湿性关节严重骨骼和软骨损伤。在增生性滑膜中，核心执行作用的细胞是类纤维母细胞样滑膜细胞，它们可以侵袭软骨，引发炎症，破坏关节，并显示出肿瘤样的抗凋亡特性。本研究重点研究了冷等离子体对增生性滑膜的影响，结果显示冷等离子体（CAP）治疗后未观察到滑膜增生、血管生成或炎症浸润。分子和细胞机制还揭示了自发性活性氧自由基（ROS）级联引发类风湿性关节炎类纤维母细胞样滑膜细胞（RA-FLS）凋亡。本研究提出了一种治疗增生性滑膜的潜在物理疗法，同时为冷等离子体在其他类型的肿瘤疾病中的应用提供了思路。版权所有 © 2023. 由Elsevier B.V.出版。
The most significant pathological change in rheumatoid arthritis (RA) is synovial hyperplasia within the joint. The production of a series of degrading enzymes and oxidative stress caused by synovial hyperplasia lead to severe bone and cartilage damage in rheumatoid joints. The core effector cell in hyperplastic synovium is fibroblast-like synovium cells, which can invade cartilage, cause inflammation, destroy joints, and show tumor-like anti-apoptosis characteristics. This study focused on the effect of cold atmospheric pressure plasma on proliferative synovium, and the results showed that no synovial hyperplasia, angiogenesis, or inflammatory infiltration was observed after cold atmospheric pressure plasma (CAP) treatment. The molecular and cellular mechanisms also reveal the spontaneous reactive oxygen species (ROS) cascade inducing apoptosis in rheumatoid arthritis fibroblast-like synoviocytes (RA-FLS) cells. This study proposes a potential physical therapy method for treating proliferative synovium and also provides ideas for the application of CAP in other types of tumor diseases.Copyright © 2023. Published by Elsevier B.V.