高血糖导致的心脏肥大和心脏炎症是糖尿病心肌病的重要病理过程。β-elemene（Ele）是从姜黄根茎中提取的天然化合物，具有抗肿瘤作用。它在一些炎症性疾病中也具有治疗效果。然而，Ele对糖尿病心肌病的治疗效果尚不清楚。本研究旨在评估Ele对高血糖引起的心脏重塑和心力衰竭的影响。将C57BL/6小鼠腹腔注射链脲佐菌素诱导DCM，并在8周后经口给予Ele进行实验。对心脏组织进行RNA测序以研究其机制。Ele显著抑制糖尿病小鼠以及高葡萄糖诱导的心肌细胞的心脏炎症、纤维化和肥大。RNA测序显示，Ele的心脏保护作用涉及JAK/STAT3-NF-κB信号通路。Ele通过阻断糖尿病诱导的JAK2和STAT3磷酸化以及NF-κB激活，在小鼠心脏和心肌细胞中减轻了炎症反应。研究发现，Ele通过抑制JAK/STAT3和NF-κB介导的炎症反应来保护糖尿病小鼠的心脏，这表明Ele是糖尿病心肌病的有效治疗方法。版权所有©2023，Elsevier GmbH发布。

Hyperglycemic induced cardiac hypertrophy and cardiac inflammation are important pathological processes in diabetic cardiomyopathy. β-elemene (Ele) is a natural compound extracted from Curcuma Rhizoma and has anti-tumor effects. It also has therapeutic effects in some inflammatory diseases. However, the therapeutic effect of Ele on diabetic cardiomyopathy is not clear. The purpose of this study was to evaluate the effect of Ele on hyperglycemia-caused cardiac remodeling and heart failure.C57BL/6 mice were intraperitoneally injected with streptozotocin to induce DCM, and Ele was administered intragastric after 8 weeks to investigate the effect of Ele. RNA sequencing of cardiac tissue was performed to investigate the mechanism.Ele markedly inhibited cardiac inflammation, fibrosis and hypertrophy in diabetic mice, as well as in high glucose-induced cardiomyocytes. RNA sequencing showed that cardioprotective effect of Ele involved the JAK/STAT3-NF-κB signaling pathway. Ele alleviated heart and cardiomyocyte inflammation in mice by blocking diabetes-induced JAK2 and STAT3 phosphorylation and NF-κB activation.The study found that Ele preserved the hearts of diabetic mice by inhibiting JAK/STAT3 and NF-κB mediated inflammatory responses, suggesting that Ele is an effective therapy for DCM.Copyright © 2023. Published by Elsevier GmbH.