本研究重点关注保加利亚的患者队列，他们患有单一记录的慢性并发症 - 心血管病理、肿瘤性疾病或慢性肺部疾病（CPD），并比较国家层面上接种疫苗和未接种疫苗的人群在门诊、医院和重症监护室（ICU）设施中的结果，按性别和年龄组进行分类。回顾性分析设置、参与者和结果评估：在总共1126,946例经由卫生部于2020年3月至2022年4月启动的联合信息门户网站提供的数据来回顾性分析，这些患者被确诊为COVID-19，涉及到国家层面。在所有确诊的247,441例COVID-19住院病例中，67,723例（27.3％）患有已记录的心血管疾病（CVD），2,140例（0.9％）患有已证实的实体恶性肿瘤（无论阶段如何），3,243例（1.3％）仅已确立CPD为其慢性病理。在每个亚组中，累计死亡人数分别为10,165例（住院=5,812例，ICU=4,353例）；其中4.0％接种疫苗（410/10,165例，p＜0.001），344例（住院=196例，ICU=148例），4.9％接种疫苗（17/344例，p＜0.001），494例（住院=287例，ICU=207例），5.2％接种疫苗（26/494例，p＜0.001）。在接种疫苗队列中，以减少门诊、住院以及住院和ICU相关死亡率的优势取得了统计学上的显著性（p＜0.001），而BNT162b2在所有年龄组中防止死亡的效果最好。这项回顾性分析表明，接种COVID-19疫苗的患者在患有心血管疾病、实体恶性肿瘤或作为单一并发症的CPD患者中，呈现出减少住院和过早死亡的趋势。 © 作者（或其雇主） 2023年。在CC BY-NC权限下允许重新使用。不得进行商业再利用。由BMJ出版。

This study focused on Bulgarian patient cohorts harbouring a single documented chronic comorbidity-cardiovascular pathology, an oncological disease or a chronic pulmonary diseases (CPD) comparing the outcomes in fully vaccinated and non-vaccinated populations classified by sex and age groups in ambulatory, hospital and intensive care unit (ICU) settings at the national level.Retrospective analysis SETTINGS, PARTICIPANTS AND OUTCOME MEASURES: In total, 1 126 946 patients with confirmed COVID-19, on a national level, were retrospectively analysed between March 2020 and April 2022, using data from the Ministry of Health's United Information Portal, launched in March 2020.Of all the confirmed 247 441 hospitalised cases of COVID-19, 67 723 (27.3%) had documented cardiovascular disease (CVD), 2140 (0.9%) had confirmed solid malignancy (regardless of stage) and 3243 (1.3%) had established CPD as their only chronic pathology. The number of cumulative deaths in each subgroup was 10 165 (in-hospital=5812 and ICU=4353); 4.0% vaccinated (410/10 165, p<0.001), 344 (in-hospital=196 and ICU=148), 4.9% vaccinated (17/344, p<0.001), 494 (in-hospital=287 and ICU=207) and 5.2% vaccinated (26/494, p<0.001), respectively. Statistical significance (p<0.001) was obtained in favour of reduced ambulatory, hospitalisation and both in-hospital and ICU-related mortality in the vaccinated cohorts, and BNT162b2 was the most effective at preventing mortality in all age groups.This retrospective analysis shows that patients vaccinated against COVID-19 demonstrated trends of reduced hospitalisations and premature mortality in patients with CVD, solid malignancy or CPD as a single comorbidity.© Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.