即使进行完全切除，胶质母细胞瘤患者仍会在远离原发肿瘤部位的对侧脑半球发生复发。这是疾病生存期短的主要原因之一。本研究的目的是使用全自动轨迹空间统计学（TBSS）方法，利用不同扩散模型检测胶质母细胞瘤患者对侧脑半球的微观结构变化。研究对象包括未接受任何治疗的14例右侧和11例左侧胶质母细胞瘤患者，以及18例与之年龄和性别匹配的对照组。采用3T磁共振成像设备生成了多壳扩散加权图像。经过多个预处理步骤后，得到了关于固有各向异性（FA）、平均弥散性（MD）、轴向弥散性（AD）、径向弥散性（RD）、轴向峰度（AK）、平均峰度（MK）、径向峰度（RK）、胞内体积分数（ICVF）、取向分散指数（ODI）和各向同性水分数（ISO）的图像。利用TBSS方法，比较对侧脑半球的扩散张量成像、扩散峰值成像和纤维取向分散和密度成像参数在右侧和左侧胶质母细胞瘤患者与对照组之间的差异。右侧和左侧胶质母细胞瘤患者的对侧脑半球中都显示了MD和ODI的增加。而右侧胶质母细胞瘤患者在对侧脑半球中显示了RD、AD和ISO的增加，范围较为有限，左侧胶质母细胞瘤患者显示了MK和AK的增加。FA、ICVF和RK在两组中都没有显示出任何差异。在胶质母细胞瘤患者的对侧脑半球存在微观结构变化，并且这些变化在右侧和左侧胶质母细胞瘤患者之间存在差异。

Glioblastoma patients develop recurrence in the opposite hemisphere far from the primary tumor site even after complete resection. This is one of the main reasons for short disease survival. Our aim in this study is to detect microstructural changes in the contralateral hemisphere of glioblastoma patients using different diffusion models with the fully automated tract-based spatial statistics (TBSS) method.Fourteen right-sided and eleven left-sided glioblastoma patients without any treatment and eighteen age- and gender-matched controls were included in the study. Multi-shell diffusion weighted images were created with a 3T MRI device. After various preprocessing steps, images of fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD), radial diffusivity (RD), axial kurtosis (AK), mean kurtosis (MK), radial kurtosis (RK), intracellular volume fraction (ICVF), orientation dispersion index (ODI), and isotropic water fraction (ISO) were obtained. TBSS was used to compare diffusion tensor imaging, diffusion kurtosis imaging, and neurite orientation dispersion and density imaging parameters of right- and left-sided glioblastoma patients with the control group for the contralateral hemisphere.Both right-sided and left-sided glioblastoma patients have shown an increase in MD and ODI in the contralateral hemisphere. While right-sided glioblastoma patients showed an increase in RD, AD, and ISO in a more limited area in the contralateral hemisphere, left-sided glioblastoma patients showed an increase in MK and AK. FA, ICVF, and RK did not show any difference in both groups.There are microstructural changes in the contralateral hemisphere in glioblastoma patients, and these changes differ between right-sided and left-sided glioblastoma patients.