基质金属蛋白酶敏感型药物传递系统。
Matrix Metalloproteinase-Responsive Drug Delivery Systems.
发表日期：2023 Aug 02
作者：
Chenyun Zhang, Gan Jiang, Xiaoling Gao
来源：
BIOCONJUGATE CHEMISTRY
摘要：
基质金属蛋白酶（MMPs）是一类依赖锌和促进细胞外基质（ECM）蛋白降解的内切酶，在人类生理和病理过程中起关键作用。MMPs调节正常组织和细胞功能，包括组织发育、重塑、血管生成、骨形成和伤口愈合。多种疾病，包括癌症、炎症、心血管疾病和神经系统疾病，与特定MMP亚型的表达失调有关，这些MMP可以促进肿瘤进展、转移和炎症反应。利用受MMP活性和过表达所在区域的切割活性已开发出多种MMP响应型药物输送和释放系统。在本文中，我们回顾了不同MMP的结构、底物以及其在生理和病理过程中的功能，并强调设计MMP响应型纳米颗粒以提高治疗药物的靶向效率、穿透性和保护性的策略。
Matrix metalloproteinases (MMPs) are a class of endopeptidases that are dependent on zinc and facilitate the degradation of extracellular matrix (ECM) proteins, thereby playing pivotal parts in human physiology and pathology. MMPs regulate normal tissue and cellular functions, including tissue development, remodeling, angiogenesis, bone formation, and wound healing. Several diseases, including cancer, inflammation, cardiovascular diseases, and nervous system disorders, have been linked to dysregulated expression of specific MMP subtypes, which can promote tumor progression, metastasis, and inflammation. Various MMP-responsive drug delivery and release systems have been developed by harnessing cleavage activities and overexpression of MMPs in affected regions. Herein, we review the structure, substrates, and physiological and pathological functions of various MMPs and highlight the strategies for designing MMP-responsive nanoparticles to improve the targeting efficiency, penetration, and protection of therapeutic payloads.