肺腺癌作为世界第二常见的癌症，预后不佳，5年生存率较低。MS4A蛋白家族对疾病的发展与进展至关重要，特别是在癌症、过敏、代谢性疾病、自身免疫性疾病、感染和神经退行性疾病中。然而，其在肺腺癌中的作用仍不清楚。本研究发现，在肺腺癌中11个MS4A家族基因上调或下调。此外，我们描述了肺腺癌中MS4A家族的遗传变异景观。值得注意的是，通过功能富集分析，我们发现MS4A家族参与免疫应答调节信号通路和免疫应答调节细胞表面受体信号通路。根据Kaplan-Meier曲线，肺腺癌患者中MS4A2、MS4A7、MS4A14和MS4A15低表达与低总生存率相关。这四个预后基因与免疫浸润细胞密切相关，整合它们的预后模型可能比当前模型更准确地预测肺腺癌患者的总生存率。本研究的发现为肺腺癌的鉴定和管理提供了创造性的建议和推荐。版权所有©2023年郑、李、杨和郭。

Lung adenocarcinoma, which is the second most prevalent cancer in the world, has a poor prognosis and a low 5-year survival rate. The MS4A protein family is crucial to disease development and progression, particularly for cancers, allergies, metabolic disorders, autoimmune diseases, infections, and neurodegenerative disorders. However, its involvement in lung adenocarcinoma remains unclear. In this study, we found that 11 MS4A family genes were upregulated or downregulated in lung adenocarcinoma. Furthermore, we described the genetic variation landscape of the MS4A family in lung adenocarcinoma. Notably, through functional enrichment analysis, we discovered that the MS4A family is involved in the immune response regulatory signaling pathway and the immune response regulatory cell surface receptor signaling pathway. According to the Kaplan-Meier curve, patients with lung adenocarcinoma having poor expression of MS4A2, MS4A7, MS4A14, and MS4A15 had a low overall survival rate. These four prognostic genes are substantially associated with immune-infiltrating cells, and a prognosis model incorporating them may more accurately predict the overall survival rate of patients with lung adenocarcinoma than current models. The findings of this study may offer creative suggestions and recommendations for the identification and management of lung adenocarcinoma.Copyright © 2023 Zheng, Li, Yang and Guo.