IL-34引发对X射线治疗和奥沙利铂化疗等细胞毒性抗癌疗法的耐药机制。
A mechanism of IL-34-induced resistance against cytotoxic anti-cancer therapies such as radiation by X-ray and chemotherapy by Oxaliplatin.
发表日期：2023
作者：
Nanumi Han, Haruka Wada, Takuto Kobayashi, Ryo Otsuka, Ken-Ichiro Seino
来源：
OncoImmunology
摘要：
白细胞介素34（IL-34）已知是参与肿瘤进展和治疗抵抗的因子。然而，IL-34诱导治疗抵抗的机制存在一定的限制。在这里，我们展示了IL-34诱导抗癌细胞毒性疗法（如X射线放疗和奥沙利铂化疗）抵抗的机制。本研究表明，IL-34在放疗或奥沙利铂等化疗药物治疗后通过免疫手段改变肿瘤微环境。我们使用流式细胞术和免疫荧光染色鉴定了免疫细胞的变化，这些变化在存在IL-34时上调。总体而言，这些发现表明，IL-34阻滞可能作为一种新型癌症联合治疗的可能性。© 2023 The Author(s). Published with license by Taylor & Francis Group, LLC.
Interleukin-34 (IL-34) has been known as a factor that is involved with tumor progression and therapeutic resistance. However, there are limitations to addressing the mechanism of how IL-34 induces therapeutic resistance. Here, we show a mechanism of IL-34-induced resistance against cytotoxic anti-cancer therapies such as radiotherapy using X-ray and chemotherapy by Oxaliplatin. This research demonstrates that IL-34 immunologically changes the tumor microenvironment after treatments with radiation or chemotherapeutic agents such as oxaliplatin. We identified the changes in immune cells using flow cytometry and immunofluorescent (IF) staining, which are up-regulated upon the existence of IL-34. Overall, these findings demonstrate the possibility of IL-34 blockade as a novel combination therapy for cancer.© 2023 The Author(s). Published with license by Taylor & Francis Group, LLC.