线粒体损伤相关分子在创伤引发的全身性炎症反应综合征中的作用。
The role of mtDAMPs in the trauma-induced systemic inflammatory response syndrome.
发表日期：2023
作者：
Jingjing Ye, Xiaodan Hu, Zhiwei Wang, Rui Li, Lebin Gan, Mengwei Zhang, Tianbing Wang
来源：
Frontiers in Immunology
摘要：
全身性炎症反应综合征（SIRS）是一种由感染性或非感染性应激因素（如创伤、烧伤、手术、缺血再灌注和恶性肿瘤）引起的非特异性过度防御反应，最终导致无法控制的炎症反应。除了创伤后由“首次打击”引起的早期死亡外，创伤引起的SIRS和多器官功能障碍综合征（MODS）是创伤患者预后不良的主要原因，即“次次打击”。与由病原体相关的分子模式（PAMPs）引起的感染性SIRS不同，创伤引起的SIRS主要通过损伤相关的分子模式（DAMPs）介导，包括线粒体损伤后释放的线粒体DAMPs（mtDAMPs）。创伤引起的线粒体损伤释放的mtDAMPs包括线粒体DNA（mtDNA）和线粒体甲酰肽（mtFPs），通过多种炎症信号途径激活炎症反应。本综述总结了mtDAMPs在创伤引起的SIRS发生和发展中的作用和机制。版权所有©2023年叶氏、胡氏、王氏、李氏、甘氏、张氏和王氏。
Systemic inflammatory response syndrome (SIRS) is a non-specific exaggerated defense response caused by infectious or non-infectious stressors such as trauma, burn, surgery, ischemia and reperfusion, and malignancy, which can eventually lead to an uncontrolled inflammatory response. In addition to the early mortality due to the "first hits" after trauma, the trauma-induced SIRS and multiple organ dysfunction syndrome (MODS) are the main reasons for the poor prognosis of trauma patients as "second hits". Unlike infection-induced SIRS caused by pathogen-associated molecular patterns (PAMPs), trauma-induced SIRS is mainly mediated by damage-associated molecular patterns (DAMPs) including mitochondrial DAMPs (mtDAMPs). MtDAMPs released after trauma-induced mitochondrial injury, including mitochondrial DNA (mtDNA) and mitochondrial formyl peptides (mtFPs), can activate inflammatory response through multiple inflammatory signaling pathways. This review summarizes the role and mechanism of mtDAMPs in the occurrence and development of trauma-induced SIRS.Copyright © 2023 Ye, Hu, Wang, Li, Gan, Zhang and Wang.