靶向p53蛋白的寡聚聚集可能增强中风后的血管生成反应。
Potential enhancement of post-stroke angiogenic response by targeting the oligomeric aggregation of p53 protein.
发表日期：2023
作者：
Hoi Hei Tam, Dongxing Zhu, Samuel Sze King Ho, Heng Wai Vong, Vincent Kam Wai Wong, Simon Wing-Fai Mok, Io Nam Wong
来源：
Frontiers in Cellular Neuroscience
摘要：
发现抑癌基因p53及其聚集体参与了许多与血管生成相关的途径。我们探索了缺血性卒中后常见的p53聚集体形成机制，如缺氧和活性氧（ROS）的存在。涉及p53的血管生成途径主要发生在细胞核或细胞质中，但有一个例外是发生在线粒体中的。考虑到大脑和内皮细胞中存在高密度的线粒体，我们提出在线粒体中发生的蛋白环状琥珀酸盐D（CypD）依赖的血管内皮细胞坏死途径是影响血管生成的主要因素之一。因此，靶向p53聚集体，这一途径中的关键中间体，可能是卒中后治疗的替代治疗目标。版权所有 © 2023 Tam, Zhu, Ho, Vong, Wong, Mok和Wong。
Tumor suppressor gene p53 and its aggregate have been found to be involved in many angiogenesis-related pathways. We explored the possible p53 aggregation formation mechanisms commonly occur after ischemic stroke, such as hypoxia and the presence of reactive oxygen species (ROS). The angiogenic pathways involving p53 mainly occur in nucleus or cytoplasm, with one exception that occurs in mitochondria. Considering the high mitochondrial density in brain and endothelial cells, we proposed that the cyclophilin D (CypD)-dependent vascular endothelial cell (VECs) necrosis pathway occurring in the mitochondria is one of the major factors that affects angiogenesis. Hence, targeting p53 aggregation, a key intermediate in the pathway, could be an alternative therapeutic target for post-stroke management.Copyright © 2023 Tam, Zhu, Ho, Vong, Wong, Mok and Wong.