研究动态
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临床与管理困境:妊娠期早期阶段宫颈癌的病例报告。

Clinical and Management Dilemmas Concerning Early-Stage Cervical Cancer in Pregnancy - A Case Report.

发表日期:2023
作者: Andi Kurniadi, Dani Setiawan, Jessica Kireina, Dodi Suardi, Siti Salima, Febia Erfiandi, Mia Yasmina Andarini
来源: PHYSICAL THERAPY & REHABILITATION JOURNAL

摘要:

妊娠期宫颈癌罕见,其管理仍然是一个严峻的挑战。临床上的分期升级是个严重的问题。表现可能类似于与妊娠相关的状况,从而延迟诊断并导致晚期就诊。此外,对于妊娠期化疗安全的顾虑可能阻碍其使用。由于怀孕的原因,明确的治疗可能也会延迟。一个37岁、G3P2A0孕10-11周的妇女被诊断为IB2期宫颈癌。我们最初计划进行新辅助化疗,使用纳氧嘧啶175mg/m2和卡铂6 AUC,每21天一次,然后进行剖宫产和根治性子宫切除术。然而,在术前,肿瘤进一步生长并进展到IIB期。因此需进行产后放疗。我们进行了下段剖宫产,同时进行了双侧输卵管切除和卵巢移位术。通过外照射放疗和近距离放疗进行放疗。患者生下一名体重低于孕龄的健康男婴。2个月的随访中,婴儿整体上看起来健康。妊娠期癌症的诊断对妇女的身体和心理状态有不良影响。症状可能类似于与妊娠相关的状况,从而延迟诊断。其管理需要多学科团队来保护孕妇和胎儿的健康。© 2023 Kurniadi等。
Cervical cancer in pregnancy is rare and its management remains a formidable challenge. Clinical upstaging is a serious concern. Presentation may mimic pregnancy-related conditions, thus delaying diagnosis and leading to an advanced stage at presentation. In addition, concerns regarding chemotherapy safety in pregnancy may hinder its administration. Definitive therapy may also be delayed due to pregnancy.A 37-year-old G3P2A0 10-11 weeks pregnant woman was diagnosed with stage IB2 cervical cancer. We originally planned to perform neoadjuvant chemotherapy with paclitaxel 175mg/m2 and carboplatin 6 AUC every 21 days followed by caesarean section and radical hysterectomy. However, preoperatively, the tumor had grown further and progressed to stage IIB. Postpartum radiotherapy was thus indicated. Lower segmental caesarean section along with bilateral salpingectomy and ovarian transposition were performed. Radiotherapy was administered through external beam radiation therapy and brachytherapy. The patient delivered a small for gestational age male baby with no abnormalities. At 2-month follow-up, the infant appeared generally healthy.Cancer diagnosis during pregnancy adversely impacts women's physical and psychological states. Symptoms may mimic pregnancy-related conditions, thus delaying diagnosis. Its management involves a multidisciplinary team to protect both maternal and fetal health.© 2023 Kurniadi et al.