乳腺癌（BC）是全球最常见的癌症类型，也是导致女性因癌症死亡的主要原因。由于传统治疗方法如化疗和放疗的明显副作用，研究人员对低毒性和副作用较小的补充和替代天然药物的寻求感兴趣。姜黄素（CUR）是从姜黄中提取的天然多酚化合物。许多研究已经证明，CUR是一种有效的抗癌药物，通过改变不同的细胞内信号传导通路起作用。然而，CUR的治疗效果受到其在体内的半衰期短、溶解度低、稳定性差、代谢快、口服生物利用度低以及高口服剂量可能导致的胃肠不适等问题的严重限制。针对上述问题的最实用解决方案之一是基于纳米材料开发的靶向药物传递系统（TDDSs）。本综述就CUR的理化特性、生物利用度及其对BC的作用机制进行介绍，并重点介绍了近期关于BC的CUR TDDSs的研究，包括被动TDDSs、主动TDDSs和理化TDDSs，以改善药物的靶向性和疗效，并为CUR TDDSs在临床应用中的开发和使用提供参考。© 2023 黄等。

Breast cancer (BC) is the most prevalent type of cancer in the world and the main reason women die from cancer. Due to the significant side effects of conventional treatments such as chemotherapy and radiotherapy, the search for supplemental and alternative natural drugs with lower toxicity and side effects is of interest to researchers. Curcumin (CUR) is a natural polyphenol extracted from turmeric. Numerous studies have demonstrated that CUR is an effective anticancer drug that works by modifying different intracellular signaling pathways. CUR's therapeutic utility is severely constrained by its short half-life in vivo, low water solubility, poor stability, quick metabolism, low oral bioavailability, and potential for gastrointestinal discomfort with high oral doses. One of the most practical solutions to the aforementioned issues is the development of targeted drug delivery systems (TDDSs) based on nanomaterials. To improve drug targeting and efficacy and to serve as a reference for the development and use of CUR TDDSs in the clinical setting, this review describes the physicochemical properties and bioavailability of CUR and its mechanism of action on BC, with emphasis on recent studies on TDDSs for BC in combination with CUR, including passive TDDSs, active TDDSs and physicochemical TDDSs.© 2023 Huang et al.