植物雌激素是存在于300种植物中的非类固醇多酚物质。关于其与雌二醇的结构相似性，植物雌激素可以结合到雌激素受体，并表现出抗雌激素或促雌激素的活性。本综述文章探讨了植物雌激素在疾病管理中的潜在优势和自噬特性，重点强调了植物雌激素如何通过调节自噬来发挥作用。研究已经探讨了植物雌激素在预防和治疗各种疾病中的潜在益处，包括更年期症状、肿瘤、皮肤老化、骨质疏松症、心脏病、神经退行性疾病、免疫系统疾病和代谢综合征，这些益处归功于其治疗效果。由于植物雌激素可以激活或抑制自噬，自噬在癌症和衰老性疾病中具有抗氧化、凋亡、抗突变、抗癌、转录和基因组影响的作用，植物雌激素通过调节自噬可能影响这些疾病。动物模型的合作性研究、遗传技术的应用以及药理活性物质的管理已经显示出自噬调节在各种疾病中的可能治疗益处。需要进一步研究以阐明植物雌激素调节自噬的途径以及对这些疾病的可能治疗效果。版权所有: © Journal of Advanced Veterinary and Animal Research.

Phytoestrogens are non-steroid polyphenolic materials present in 300 plants. Regarding their structural similarities to estradiol, phytoestrogens attach to estrogen receptors and display anti- or pro-estrogenic activities. This review explored phytoestrogens' potential advantages and autophagy properties in light of their future application for disease management, highlighting how phytoestrogens could modulate autophagy. Research has examined the prospective benefits of phytoestrogens for the anticipation and management of various conditions, including signs of menopause, tumors, skin deterioration, osteoporosis, heart disease, neurodegenerative conditions, disorders of the immune system, and metabolic syndrome, owing to their therapeutic effects. As phytoestrogens can activate or inhibit autophagy, which has antioxidant, apoptotic, anti-mutagenic, anticancer, transcriptional, and genomic impacts on cancer and aging illnesses, phytoestrogens could influence diseases through the modulation of autophagy. The collaborative research on animal models, utilization of genetic techniques, and administration of pharmacologically active substances has indicated the possible therapeutic benefits of autophagy modulation in various illnesses. Further research is required to illustrate the pathways by which phytoestrogens modulate autophagy and the possible therapeutic effects on these diseases.Copyright: © Journal of Advanced Veterinary and Animal Research.