细胞外囊泡在乳腺癌的治疗和诊断中的应用：进展概述。
Extracellular vesicles in the treatment and diagnosis of breast cancer: a status update.
发表日期：2023
作者：
Xiaoying Zhang, Caizheng Wang, Jiahui Yu, Jiawen Bu, Fulv Ai, Yue Wang, Jie Lin, Xudong Zhu
来源：
Frontiers in Endocrinology
摘要：
乳腺癌是妇女癌症相关死亡的主要原因之一。目前，乳腺癌的治疗受到有效靶向疗法缺乏的限制，患者常常遭受更严重的病情、转移和耐药性。胞外囊泡（EVs）由包裹复杂负载的脂质双层组成，其中包括蛋白质、核酸和代谢物。这些生物活性负载在乳腺癌的发生和进展中起到关键作用。此外，EV负载在广泛诱导增殖、血管生成、前转移微环境形成、迁移和药物耐药性方面发挥了核心作用，将乳腺细胞转化为致癌细胞和转移灶。本综述主要讨论来自乳腺癌细胞和肿瘤源性EV的负载，并侧重于增殖、转移、药物耐药性以及它们作为有效生物标志物的临床潜力。版权所有©2023张、王、于、卜、艾、汪、林和朱。
Breast cancer is one of the leading causes of cancer-related death in women. Currently, the treatment of breast cancer is limited by the lack of effectively targeted therapy and patients often suffer from higher severity, metastasis, and resistance. Extracellular vesicles (EVs) consist of lipid bilayers that encapsulate a complex cargo, including proteins, nucleic acids, and metabolites. These bioactive cargoes have been found to play crucial roles in breast cancer initiation and progression. Moreover, EV cargoes play pivotal roles in converting mammary cells to carcinogenic cells and metastatic foci by extensively inducing proliferation, angiogenesis, pre-metastatic niche formation, migration, and chemoresistance. The present update review mainly discusses EVs cargoes released from breast cancer cells and tumor-derived EVs in the breast cancer microenvironment, focusing on proliferation, metastasis, chemoresistance, and their clinical potential as effective biomarkers.Copyright © 2023 Zhang, Wang, Yu, Bu, Ai, Wang, Lin and Zhu.