TNF + 调节性 T 细胞通过 IL13/STAT3 途径调控胃癌细胞的干细胞性。
TNF+ regulatory T cells regulate the stemness of gastric cancer cells through the IL13/STAT3 pathway.
发表日期：2023
作者：
Rou Zhao, Guanjie Cao, Baogui Zhang, Li Wei, Xiaobei Zhang, Meng Jin, Baoyu He, Bin Zhang, Zhun He, Qingli Bie
来源：
Stem Cell Research & Therapy
摘要：
调控性T细胞（Tregs）是肿瘤微环境的重要组成部分，然而，Tregs与胃癌细胞之间的相互作用仍不完全清楚。最近的研究表明，Tregs参与了癌细胞干细胞性的维持。在本研究中，我们对胃癌和相邻组织进行了单细胞RNA测序，发现具有高TNF表达的Tregs被招募到胃癌组织中，并且与患者的生存显著相关。TNF+ Tregs显著促进肿瘤的生长和进展。我们的研究进一步证明，TNF+ Tregs通过IL13/STAT3途径促进胃癌细胞的干细胞性。因此，阻断TNF+ Tregs与胃癌细胞之间的相互作用可能是治疗胃癌的一种新方法。版权所有 © 2023 Zhao, Cao, Zhang, Wei, Zhang, Jin, He, Zhang, He and Bie.
Regulatory T cells (Tregs) are an important component of the tumor microenvironment; however, the interaction between Tregs and gastric cancer cells is not completely understood. Recent studies have shown that Tregs participate in cancer cell stemness maintenance. In this study, we performed single-cell RNA sequencing of gastric cancer and adjacent tissues and found that Tregs with high TNF expression were recruited to gastric cancer tissues and were significantly correlated with patient survival. TNF+ Tregs significantly contribute to tumor growth and progression. Our studies have further demonstrated that TNF+ Tregs promote the stemness of gastric cancer cells through the IL13/STAT3 pathway. Therefore, blocking the interaction between TNF+ Tregs and gastric cancer cells may be a new approach in the treatment of gastric cancer.Copyright © 2023 Zhao, Cao, Zhang, Wei, Zhang, Jin, He, Zhang, He and Bie.