进行垂体手术的患者可能会出现术后短期和长期的发病率。术中因素，如低血压可能是一个促发因素。我们的目的是调查术中低血压与术后血浆tau、轻神经纤维蛋白（NfL）和胶质纤维酸性蛋白（GFAP）浓度的关联，作为围手术期脑损伤的标志物。从2016年6月至2017年10月，共纳入了Gothenburg Pituitary Tumor Study的35名患者。测量了tau、NfL和GFAP在手术前、手术后立即、术后第1天和第5天的血浆样本浓度。使用术后最高值与手术前值之间的差异进行分析（∆taupeak，∆NfLpeak，∆GFAPpeak）。术中低血压被定义为绝对阈值低于70 mmHg（AUC70）和基线平均动脉血压的相对阈值低于20%（AUC20%）的曲线下面积。术后立即和第1天，血浆tau和GFAP最高，而NfL在第5天最高。AUC20%与∆taupeak（r2 = .20, p < .001）和∆NfLpeak（r2 = .26, p < .001）之间存在正相关。AUC20%与GFAP之间以及AUC70与∆taupeak、∆NfLpeak 或 ∆GFAPpeak之间未发现关联。术中相对低血压与术后血浆tau和NfL浓度增加相关。进行垂体手术的患者可能对相对低血压较为脆弱，但这需要在未来的前瞻性研究中进行验证。 © 2023 作者. Acta Anaesthesiologica Scandinavica由John Wiley & Sons Ltd代表Acta Anaesthesiologica Scandinavica Foundation发表。

Patients undergoing pituitary surgery may experience short- and long-term postoperative morbidity. Intraoperative factors such as hypotension might be a contributing factor. Our aim was to investigate the association between intraoperative hypotension and postoperative plasma levels of tau, neurofilament light (NfL), and glial fibrillary acidic protein (GFAP) as markers of perioperative brain injury.Between June 2016 and October 2017, 35 patients from the Gothenburg Pituitary Tumor Study were included. For tau, NfL, and GFAP, concentrations were measured in plasma samples collected before and immediately following surgery, and on postoperative days 1 and 5. The difference between the highest postoperative value and the value before surgery was used for analysis (∆taupeak , ∆NfLpeak , ∆GFAPpeak ). Intraoperative hypotension was defined as the area under the curve of an absolute threshold below 70 mmHg (AUC70) and a relative threshold below 20% (AUC20%) of the baseline mean arterial blood pressure.Plasma tau and GFAP were highest immediately following surgery and on day 1, while NfL was highest on day 5. There was a positive correlation between AUC20% and both ∆taupeak (r2  = .20, p < .001) and ∆NfLpeak (r2  = .26, p < .001). No association was found between AUC20% and GFAP or between AUC70 and ∆taupeak , ∆NfLpeak or ∆GFAPpeak .Intraoperative relative, but not absolute, hypotension was associated with increased postoperative plasma tau and NfL concentrations. Patients undergoing pituitary surgery may be vulnerable to relative hypotension, but this needs to be validated in future prospective studies.© 2023 The Authors. Acta Anaesthesiologica Scandinavica published by John Wiley & Sons Ltd on behalf of Acta Anaesthesiologica Scandinavica Foundation.