催化苷在多种炎症性疾病中的抗炎作用及机制
Anti-inflammatory effect and mechanism of catalpol in various inflammatory diseases.
发表日期：2023 Aug 03
作者：
Jinyao Liu, Shuang Liu, Mingyue Yu, Jianing Li, Zunxuan Xie, Boyang Gao, Yuyan Liu
来源：
ANTIOXIDANTS & REDOX SIGNALING
摘要：
苦草内酯是一种广泛存在于多种植物中的脱氧基内酯葡萄糖苷，在传统草药地黄的根茎中提取较为常见。其具有抗炎、抗氧化和抗肿瘤等多种生物活性。苦草内酯的抗炎作用已在多种疾病中得到证实，包括神经疾病、动脉粥样硬化、肾脏疾病、呼吸系统疾病、消化系统疾病、骨骼关节疾病、眼科疾病和牙周病等。本综述的目的是总结过去十年来苦草内酯在多种炎症性疾病中的抗炎作用的现有文献，并重点讨论苦草内酯的抗炎机制。© 2023 Wiley Periodicals LLC.
Catalpol is a kind of iridoid glucoside, widely found in a variety of plants, mostly extracted from the rhizome of the traditional medicinal herb rehmanniae. It has various biological activities such as anti-inflammatory, antioxidant, and antitumor. The anti-inflammatory effects of catalpol have been demonstrated in a variety of diseases, such as neurological diseases, atherosclerosis, renal diseases, respiratory diseases, digestive diseases, bone and joint diseases, eye diseases, and periodontitis. The purpose of this review is to summarize the existing literature on the anti-inflammatory effects of catalpol in a variety of inflammatory diseases over the last decade and to focus on the anti-inflammatory mechanisms of catalpol.© 2023 Wiley Periodicals LLC.