癌症研究如何得益于大脑研究（反之亦然）？
How can cancer research be illuminated by brain research (and vice versa)?
发表日期：2023 Aug 03
作者：
Alexios-Fotios A Mentis, Kostas A Papavassiliou, Christina Piperi, Athanasios G Papavassiliou
来源：
Alzheimers & Dementia
摘要：
癌症和脑部研究历来沿着明确的途径进行，并且主要聚焦于研究脑癌。如今，神经肿瘤学和神经内分泌调节肿瘤发生学领域正在兴起，并得到了密集的研究和有希望的应用。越来越多的证据表明，在一些非癌性脑部疾病中普遍存在与癌症相关基因的体细胞突变。这些发现突显出癌症发展/进展与神经系统病理的某些方面共享分子改变的事实，有助于阐明癌症的独特特征，并将癌症药物重用于脑部疾病。通过这样做，识别出这些疾病之间的共同点不仅对于更好地理解这些病理的基础至关重要，而且还需要考虑利用在一种类型的病理中已知有效的药物可能具有先前未被重视和/或忽视的其他类型病理的可能性。 © 2023 UICC.
Cancer and brain research have historically followed concrete pathways and converged mostly to studying brain cancer. Nowadays, the fields of neuro-oncology and neuroendocrine regulation of tumorigenesis are both emerging fields of intense research and promising applications. An increasing body of evidence suggests that somatic mutations in cancer-related genes are prevalent in several noncancerous brain disorders. These findings highlighting that certain aspects of cancer development/progression and pathologies of the nervous system share molecular alterations, could assist in elucidating the unique hallmarks of cancer and in cancer drugs repurposing for brain disorders. In so doing, identifying the commonalities in these conditions could be crucial not only for better understanding the basis of these pathologies but also for considering the previously underappreciated and/or neglected possibility of using drugs known to be effective in one type of pathology for the other type.© 2023 UICC.