近期研究显示，与代谢过程相关的基因AHSG参与了肿瘤的多个病理过程。该研究将探讨AHSG与肺腺癌之间的关系。使用公共数据库进行AHSG的表达分析、生存分析和共表达分析，并进行细胞学和分子生物学实验以探索AHSG在肺腺癌中的作用。与正常组织相比，在TCGA-LUAD数据库中，癌细胞组织中AHSG的表达显著增高，并且全癌症分析揭示了不同类型肿瘤中AHSG的异常表达。生存分析表明，与低表达组相比，高表达组患者在TCGA-LUAD数据库中的总生存期明显较差，并随后的研究证实，AHSG的表达可以作为肺腺癌总生存期的独立预后因子。与AHSG相关的基因参与了多个生理和病理途径。在随后的细胞学和分子生物学实验中，抑制AHSG的表达抑制了肺腺癌细胞系的增殖、迁移和侵袭，并在AHSG敲除后阻断了EMT过程。AHSG可作为肺腺癌患者总生存期的预后因子，可促进肺腺癌的生物学行为，并可能成为治疗的潜在靶点，值得进一步研究。© 2023. 作者，独家授权给Springer Nature B.V.

Recent studies have shown that the metabolic process-related gene AHSG is involved in multiple pathological processes of tumours. This study will explore the relationship between AHSG and lung adenocarcinoma.Expression analysis, survival analysis and co-expression analysis of AHSG were performed using a public database, and cytological and molecular biology assays were performed to explore the role of AHSG in lung adenocarcinoma.Compared with normal tissues, AHSG expression was significantly higher in cancer tissues in the TCGA-LUAD database, and pan-cancer analysis revealed abnormal AHSG expression in different kinds of tumours. Survival analysis revealed that compared with the low expression group, the patients in the high expression group had a significantly worse overall survival duration in the TCGA-LUAD database, and a subsequent study confirmed that AHSG expression could be an independent prognostic factor of overall survival in lung adenocarcinoma. AHSG-related genes are involved in multiple physiological and pathophysiological pathways. In subsequent cytological and molecular biology experiments, inhibition of AHSG expression suppressed proliferation, migration and invasion in lung adenocarcinoma cell lines, and the EMT process was blocked after knockdown of AHSG.AHSG could be used as a prognostic factor for OS in patients with lung adenocarcinoma. It can promote the biological behaviour of lung adenocarcinoma and may become a potential target for treatment, which is worthy of further study.© 2023. The Author(s), under exclusive licence to Springer Nature B.V.