腹腔表面恶性肿瘤治疗的进展，包括细胞减灭手术和腹腔热化学灌注疗法（CRS±HIPEC），已使患者实现了长期生存，但这些患者的后续生活质量（QOL）和价值尚不清楚。通过在线支持团体向幸存者提供了调查问卷。新的项目评估了患者对体验、费用、寿命和福祉的优先次序。在回答问题的453名胃肠肝胆（GI/HPB）手术患者中，有74名接受了CRS±HIPEC手术，年龄为54±12岁，其中87%为女性，93%为白人。被调查者平均从诊断开始为29个月，最长存活期为20年。通过适度一致性（W=39%），被调查者对价值指标的排序是可预测的（p<0.001）。寿命和功能独立性排名最高，治疗经历和治疗费用排名最低（p<0.001）。接受CRS±HIPEC或其他GI/HPB手术的患者对价值排序的结果相同。CRS±HIPEC幸存者的QOL，包括心理（M-QOL）（44±13）和身体（P-QOL）（41±11），低于一般人口的水平（50±10）（p<0.001）。这些损伤在幸存期间持续存在，但M-QOL随时间而改善（p<0.05）。与其他GI/HPB癌症手术幸存者相比，CRS±HIPEC的M-QOL（43±13与43±14，p=0.85）和P-QOL（40±11与42±12，p=0.41）相似。尽管CRS±HIPEC幸存者长期经历心理和身体健康损害，但它们与其他GI/HPB癌症手术幸存者的情况相似，而且QOL在幸存过程中有显著改善。由于CRS±HIPEC幸存者将寿命优先于其他所有指标，生存益处可能超过QOL暂时的降低。©2023年。Society of Surgical Oncology.

Advances in treatment of peritoneal surface malignancies including cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CRS±HIPEC) have led to long-term survivorship, yet the subsequent quality of life (QOL) and values of these patients are unknown.Survivors were offered surveys via online support groups. Novel items assessed how patients prioritized experience, costs, longevity, and wellbeing.Of the 453 gastrointestinal/hepatobiliary (GI/HPB) surgical patients that responded, 74 underwent CRS±HIPEC and were 54±12 years old, 87% female, and 93% white. Respondents averaged 29 months from diagnosis, with a maximum survival of 20 years. With a moderate level of agreement (W = 39%), rankings of value metrics among respondents were predictable (p < 0.001). Longevity and functional independence were ranked highest; treatment experience and cost of treatment were ranked lowest (p < 0.001). Those who underwent CRS±HIPEC or other GI/HPB surgeries reported the same rank order. QOL in CRS±HIPEC survivors, both mental (M-QOL) (44±13) and physical (P-QOL) (41±11) were lower than in the general population (50±10); p < 0.001. Impairments persisted throughout survivorship, but M-QOL improved over time (p < 0.05). When comparing CRS±HIPEC with other GI/HPB cancer surgery survivors, M-QOL (43±13 versus 43±14, p = 0.85) and P-QOL (40±11 versus 42±12, p = 0.41) were similar.Although CRS±HIPEC survivors experience long-term mental and physical health impairments, they were similar to those experienced by survivors of other GI/HPB cancer surgeries, and their QOL improved significantly throughout survivorship. As CRS±HIPEC survivors prioritize longevity above all other metrics, survival benefit may outweigh a temporary reduction in QOL.© 2023. Society of Surgical Oncology.