一项关于miRNA在宫颈癌检测中的系统回顾和荟萃分析。
A systematic review and meta-analysis of miRNAs for the detection of cervical cancer.
发表日期：2023 Aug 03
作者：
Christopher Rt Hillyar, Shivani S Kanabar, Kamil R Pufal, Joshua Li Saw Hee, Alexander W Lawson, Yethrib Mohamed, Duha Jasim, Lara Reed, Kathrine S Rallis, Anjan Nibber
来源：
Cellular & Molecular Immunology
摘要：
目的：本研究旨在批判性评估miRNA在宫颈癌检测中的诊断有效性的证据。方法与材料：进行了系统回顾和荟萃分析，检索了PubMed、EMBASE和Web of Science数据库。进行了一个以个别生物标志物为单位的伞状荟萃分析。还进行了Grading of Recommendations, Assessment, Development and Evaluations（GRADE）证据评估。结果：总共包括52个miRNA。伞状荟萃分析显示在敏感性、特异性、受试特征曲线（ROC）、阳性预测值和/或阴性预测值之间存在显著的异质性。伞状效应分别为0.76（95% CI: 0.73-0.78）、0.78（95% CI: 0.75-0.81）、0.77（95% CI: 0.75-0.80）、0.75（95% CI: 0.71-0.79）和0.76（95% CI: 0.74-0.79）。结论：中等质量的证据表明miR199a-5p、miR21-5p和miR-141a在诊断性能方面表现出色。
Aim: This study aimed to critically appraise the evidence of the diagnostic effectiveness of miRNAs for the detection of cervical cancer. Methods & materials: A systematic review and meta-analysis was performed, searching PubMed, EMBASE and Web of Science. An umbrella meta-analysis of meta-analyses of individual biomarkers was performed. A Grading of Recommendations, Assessment, Development and Evaluations (GRADE) assessment of evidence was also performed. Results: A total of 52 miRNAs were included. Umbrella meta-analysis revealed significant heterogeneity in terms of sensitivity, specificity, receiver operating characteristic (ROC), positive predictive value and/or negative predictive value. Umbrella effects were 0.76 (95% CI: 0.73-0.78), 0.78 (95% CI: 0.75-0.81), 0.77 (95% CI: 0.75-0.80), 0.75 (95% CI: 0.71-0.79) and 0.76 (95% CI: 0.74-0.79), respectively. Conclusion: Moderate quality evidence suggested miR199a-5p, miR21-5p and miR-141a had excellent diagnostic performance.