癌细胞与肿瘤相关巨噬细胞之间的脂质代谢调控相互作用。
Lipid Metabolic Regulatory Crosstalk Between Cancer Cells and Tumor-Associated Macrophages.
发表日期：2023 Aug 03
作者：
Shu Liu, Ying Ying Shen, Li Yang Yin, Jianghua Liu, Xuyu Zu
来源：
Cellular & Molecular Immunology
摘要：
在肿瘤微环境中，肿瘤相关巨噬细胞（TAMs）是最丰富的细胞群体之一，对肿瘤发生、化学耐药、免疫逃避和转移起关键作用。TAMs与癌细胞之间存在重要的相互作用：一方面，肿瘤控制了浸润巨噬细胞的功能，导致TAMs重新编程，另一方面，TAMs影响癌细胞的生长。本综述聚焦于癌细胞与TAMs之间复杂关系中的脂质代谢变化。我们讨论了癌细胞脂质代谢如何影响巨噬细胞表型和代谢变化，以及改变的TAMs脂质代谢如何影响肿瘤进展。鉴定影响肿瘤细胞与TAMs之间复杂相互作用的代谢变化，也是探索新的靶向代谢重编程免疫细胞以增强其抗肿瘤潜力并绕过治疗耐药的重要步骤。我们的工作可能为抗肿瘤疗法提供新的靶点。
In the tumor microenvironment, tumor-associated macrophages (TAMs) are one of the most abundant cell populations, playing key roles in tumorigenesis, chemoresistance, immune evasion, and metastasis. There is an important interaction between TAMs and cancer cells: on the one hand, tumors control the function of infiltrating macrophages, contributing to reprogramming of TAMs, and on the other hand, TAMs affect the growth of cancer cells. This review focuses on lipid metabolism changes in the complex relationship between cancer cells and TAMs. We discuss how lipid metabolism in cancer cells affects macrophage phenotypic and metabolic changes and, subsequently, how altered lipid metabolism of TAMs influences tumor progression. Identifying the metabolic changes that influence the complex interaction between tumor cells and TAMs is also an important step in exploring new therapeutic approaches that target metabolic reprogramming of immune cells to enhance their tumoricidal potential and bypass therapy resistance. Our work may provide new targets for antitumor therapies.