目前，除了少数预防人乳头瘤病毒（HPV）疫苗外，尚无治疗HPV感染的方法。有许多前沿策略以及强效药物或草药配方可以局部应用，用于早期清除HPV感染，以避免HPV DNA融入寄主细胞基因组。这得益于宫颈癌具有明确且公认的长期癌前阶段。本综述旨在概述每种可能的治疗药物和配方，无论是天然的还是合成的，都可以局部应用于阴道，以帮助在早期癌前阶段清除HPV感染。一些抗HPV/HPV清除化合物和配方正在进行临床试验，用于高级别病变。然而，大部分化合物仍处于早期开发阶段，需要更多的研究来成为可行的HPV清除候选物。合成药物可能更有前景，因为它们可能具有更有针对性的效果，但它们也可能有显著的不良反应。另一方面，天然药物的使用更安全。它们的作用不那么特异，但副作用很少或没有。本文可以作为管理和预防癌前致癌HPV感染的有价值的信息资源。研究可以致力于开发候选药物，以便基于证据作出将其推进到临床试验，并最终将其用于预防和控制宫颈癌的市场使用的决策，宫颈癌几乎总是可以预防或早期治愈。Copyright © 2023 The Author(s). Published by Elsevier Ltd.. All rights reserved.

Except for a few preventative Human Papillomavirus (HPV) vaccines, there is currently no cure for HPV infection. There are a number of cutting-edge strategies and potent medications or herbal formulations that can be applied topically for early clearance of HPV infection before HPV DNA gets integrated into host cell genome. This is facilitated due to cervical cancer having distinct and well-recognized long precancerous stages.This review aims to outline every possible medication and formulation, both natural and synthetic, that can be applied topically as intravaginal application to help remove HPV infection at an early precancerous stage.Several anti-HPV/HPV clearance compounds and formulations for high-grade lesions are undergoing clinical trials. However, the majority of compounds are still in the early stages of development and require additional research to become viable HPV clearance candidates. Synthetic drugs may be more promising because they may have a more targeted effect; however, they may also have significant adverse effects. On the other hand, natural medications are safer to use. They are less specific, but have minimal to no adverse effects.This article may serve as a valuable resource of information for managing and preventing precancerous carcinogenic HPV infections. Research could be directed toward developing candidate drugs to make evidence-based decisions about advancing them to clinical trials and, eventually, to the market for potential use in the prevention and control of cervical cancer, which is almost always preventable or even curable if detected early.Copyright © 2023 The Author(s). Published by Elsevier Ltd.. All rights reserved.